Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P29122

PCSK6

Protein·UNIPROT:P29122

Open in the graph

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.

Function from UniProtKB (P29122), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

34 statements

34 statements · 4 reference databases · Subject: PCSK6 · Sources: gene ontology, Hetionet, Reactome, UniProt

Search this listOrder

ARHGEF5 covaries with PCSK6ProteinHetionet hetionet:covaries:5046-7984Inferred only
ZFP41 covaries with PCSK6ProteinHetionet hetionet:covaries:286128-5046Inferred only
ZNF550 covaries with PCSK6ProteinHetionet hetionet:covaries:162972-5046Inferred only
FLG interacts with PCSK6ProteinHetionet hetionet:interacts:2312-5046Inferred only
PCSK6 interacts with PMCHProteinHetionet hetionet:interacts:5046-5367Inferred only
PCSK6 interacts with RCN3ProteinHetionet hetionet:interacts:5046-57333Inferred only
PCSK6 interacts with RXRBProteinHetionet hetionet:interacts:5046-6257Inferred only
PCSK6 participates in Adherens junctions interactionsPathwayReactome R-HSA-418990Inferred only
PCSK6 participates in Assembly of active LPL and LIPC lipase complexesPathwayReactome R-HSA-8963889Inferred only
PCSK6 participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
PCSK6 participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
PCSK6 participates in Cell-cell junction organizationPathwayReactome R-HSA-421270Inferred only

Show the remaining 22

PCSK6 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
PCSK6 participates in Expression and Processing of NeurotrophinsPathwayReactome R-HSA-9036866Inferred only
PCSK6 participates in Formation of the cornified envelopePathwayReactome R-HSA-6809371Inferred only
PCSK6 participates in KeratinizationPathwayReactome R-HSA-6805567Inferred only
PCSK6 participates in NGF processingPathwayReactome R-HSA-167060Inferred only
PCSK6 participates in Plasma lipoprotein assembly, remodeling, and clearancePathwayReactome R-HSA-174824Inferred only
PCSK6 participates in Plasma lipoprotein remodelingPathwayReactome R-HSA-8963899Inferred only
PCSK6 participates in Regulation of CDH1 Expression and FunctionPathwayReactome R-HSA-9764265Inferred only
PCSK6 participates in Regulation of CDH1 posttranslational processing and trafficking to plasma membranePathwayReactome R-HSA-9768727Inferred only
PCSK6 participates in Regulation of Expression and Function of Type I Classical CadherinsPathwayReactome R-HSA-9764274Inferred only
PCSK6 participates in Regulation of Homotypic Cell-Cell AdhesionPathwayReactome R-HSA-9759476Inferred only
PCSK6 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
PCSK6 participates in Signaling by NODALPathwayReactome R-HSA-1181150Inferred only
PCSK6 participates in Signaling by NTRKsPathwayReactome R-HSA-166520Inferred only
PCSK6 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
PCSK6 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
PCSK6 regulates regulation of BMP signaling pathwayBiological processgene ontology P29122|GO:0030510Inferred only
FGG increases the expression of PCSK6ProteinHetionet hetionet:regulates:2266-5046Inferred only
GNPDA1 increases the expression of PCSK6ProteinHetionet hetionet:regulates:10007-5046Inferred only
NR2F6 increases the expression of PCSK6ProteinHetionet hetionet:regulates:2063-5046Inferred only
SLC16A1 increases the expression of PCSK6ProteinHetionet hetionet:regulates:6566-5046Inferred only
PCSK6 requires the cofactor Ca(2+)CompoundUniProt P29122Inferred only

Other names

5 names

Resolves to: PCSK6

Also called: PACE4Paired basic amino acid cleaving enzyme 4SPC4Subtilisin-like proprotein convertase 4Subtilisin/kexin-like protease PACE4

← Every protein Find it in the graph →