exercise-induced hyperinsulinism
Findings
No curated finding names exercise-induced hyperinsulinism yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Exercise-induced hyperinsulinism (EIHI) is a form of diazoxide-sensitive diffuse hyperinsulinism (DHI) characterized by episodes of hypoglycemia induced by exercise due to an inappropriate lactate and pyruvate sensitivity in pancreatic beta-cells.
Definition from the Mondo Disease Ontology (MONDO:0012396), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
HPO, annotations 2026-09-02
Features
5 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- HyperinsulinemiaHPOHP:0000842
- Hyperinsulinemic hypoglycemiaHPOHP:0000825
- HypoglycemiaHPOHP:0001943
- Hypoglycemic seizuresHPOHP:0002173
- Pancreatic islet-cell hyperplasiaHPOHP:0004510
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- SLC16A1HGNC:10922
- Strong · PanelApp Australia · Autosomal dominant · 2025
- Supportive · Orphanet · Autosomal dominant · 2021
- Limited · Labcorp Genetics (formerly Invitae) · Unknown · 2017
Where it sits
Other names
7 names
Resolves to: exercise-induced hyperinsulinism
- Also called
- EIHIexercise-induced hyperinsulinemic hypoglycemiahyperinsulinemic hypoglycemia, familial, type 7hyperinsulinism due to monocarboxylate transporter 1 deficiencyhyperinsulinism due to SLC16A1 deficiencyMCT1 hyperinsulinismmonocarboxylate transporter 1 hyperinsulinism