Proteins/UNIPROT:O43184

ADAM12

ProteinUNIPROT:O43184

Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity)..

Function from UniProtKB (O43184), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

27 statements

27 statements · 4 reference databases · Subject: ADAM12 · Sources: gene ontology, Hetionet, Reactome, UniProt

Order

SGSH covaries with ADAM12ProteinHetionet hetionet:covaries:6448-8038Inferred only
ZFP41 covaries with ADAM12ProteinHetionet hetionet:covaries:286128-8038Inferred only
EGF interacts with ADAM12ProteinHetionet hetionet:interacts:1950-8038Inferred only
ADAM12 interacts with FSTProteinHetionet hetionet:interacts:10468-8038Inferred only
ADAM12 interacts with FSTL3ProteinHetionet hetionet:interacts:10272-8038Inferred only
GRB2 interacts with ADAM12ProteinHetionet hetionet:interacts:2885-8038Inferred only
IGFBP3 interacts with ADAM12ProteinHetionet hetionet:interacts:3486-8038Inferred only
IGFBP5 interacts with ADAM12ProteinHetionet hetionet:interacts:3488-8038Inferred only
ADAM12 interacts with PACSIN3ProteinHetionet hetionet:interacts:29763-8038Inferred only
PIK3R1 interacts with ADAM12ProteinHetionet hetionet:interacts:5295-8038Inferred only
ADAM12 interacts with SH3D19ProteinHetionet hetionet:interacts:152503-8038Inferred only
SRC interacts with ADAM12ProteinHetionet hetionet:interacts:6714-8038Inferred only

Show the remaining 15

YES1 interacts with ADAM12ProteinHetionet hetionet:interacts:7525-8038Inferred only
ADAM12 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
ADAM12 participates in Invadopodia formationPathwayReactome R-HSA-8941237Inferred only
ADAM12 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ADAM12 participates in Signaling by EGFRPathwayReactome R-HSA-177929Inferred only
ADAM12 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
ADAM12 regulates positive regulation of angiogenesisBiological processgene ontology O43184|GO:0045766Inferred only
ACAT2 increases the expression of ADAM12ProteinHetionet hetionet:regulates:39-8038Inferred only
HDAC2 increases the expression of ADAM12ProteinHetionet hetionet:regulates:3066-8038Inferred only
NUCB2 increases the expression of ADAM12ProteinHetionet hetionet:regulates:4925-8038Inferred only
SLC16A1 increases the expression of ADAM12ProteinHetionet hetionet:regulates:6566-8038Inferred only
TIMP2 decreases the expression of ADAM12ProteinHetionet hetionet:regulates:7077-8038Inferred only
TSHZ3 increases the expression of ADAM12ProteinHetionet hetionet:regulates:57616-8038Inferred only
UNC13B increases the expression of ADAM12ProteinHetionet hetionet:regulates:10497-8038Inferred only
ADAM12 requires the cofactor Zn(2+)CompoundUniProt O43184Inferred only

Other names

3 names

Resolves to: ADAM12

Also called: ADAM 12Meltrin-alphaMLTN

← Every protein Find it in the graph →