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Proteins/UNIPROT:Q8WTV0
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity..
(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry. Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate..
(Microbial infection) Mediates uptake of M.fortuitum, E.coli and S.aureus..
(Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding..
Function from UniProtKB (Q8WTV0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
152 statements
152 statements · 4 reference databases · Subject: SCARB1 · Sources: gene ontology, Hetionet, Human-GEM, WikiPathways
3 reactions
a cholesterol estera cholesterol ester
Transported by SCARB1
Reaction pageLeft to rightBalance undeterminableextracellular space, lysosome
Human-GEM MAR00019CC BY 4.0Reference data
MAM01327cMAM01327e
Transported by NPC1L1 or SCARB1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06474CC BY 4.0Reference data
9 names
Resolves to: SCARB1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR11815CC BY 4.0Reference data