Proteins/UNIPROT:Q9BQK8

LPIN3

ProteinUNIPROT:Q9BQK8Phosphatidate phosphatase LPIN3

Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism..

Function from UniProtKB (Q9BQK8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

37 statements

37 statements · 7 reference databases · Subject: LPIN3 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Order

OTOP3 covaries with LPIN3ProteinHetionet hetionet:covaries:347741-64900Inferred only
PNPLA7 covaries with LPIN3ProteinHetionet hetionet:covaries:375775-64900Inferred only
PRDM8 covaries with LPIN3ProteinHetionet hetionet:covaries:56978-64900Inferred only
LPIN3 covaries with RILPProteinHetionet hetionet:covaries:64900-83547Inferred only
SAMD9 covaries with LPIN3ProteinHetionet hetionet:covaries:54809-64900Inferred only
LPIN3 covaries with TP53INP2ProteinHetionet hetionet:covaries:58476-64900Inferred only
LPIN3 covaries with ZNF26ProteinHetionet hetionet:covaries:64900-7574Inferred only
LPIN3 participates in AdipogenesisPathwayWikiPathways WP236Inferred only
LPIN3 participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
LPIN3 participates in Cell Cycle, MitoticPathwayReactome R-HSA-69278Inferred only
LPIN3 participates in Congenital generalized lipodystrophyPathwayWikiPathways WP5101Inferred only
LPIN3 participates in Depolymerization of the Nuclear LaminaPathwayReactome R-HSA-4419969Inferred only

Show the remaining 25

LPIN3 participates in Ether lipid biosynthesisPathwayWikiPathways WP5275Inferred only
LPIN3 participates in Glycerophospholipid biosynthesisPathwayReactome R-HSA-1483206Inferred only
LPIN3 participates in M PhasePathwayReactome R-HSA-68886Inferred only
LPIN3 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
LPIN3 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
LPIN3 participates in Mitotic ProphasePathwayReactome R-HSA-68875Inferred only
LPIN3 participates in Nuclear Envelope BreakdownPathwayReactome R-HSA-2980766Inferred only
LPIN3 participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
LPIN3 participates in Synthesis of PCPathwayReactome R-HSA-1483191Inferred only
LPIN3 participates in Synthesis of PEPathwayReactome R-HSA-1483213Inferred only
LPIN3 participates in Triglyceride biosynthesisPathwayReactome R-HSA-75109Inferred only
LPIN3 participates in Triglyceride metabolismPathwayReactome R-HSA-8979227Inferred only
LPIN3 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q9BQK8|GO:0045944Inferred only
LPIN3 requires the cofactor magnesium(2+)CompoundUniProt Q9BQK8Inferred only
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol is a substrate of LPIN3CompoundHuman-GEM MAR01352Inferred only
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate is a substrate of LPIN3CompoundHuman-GEM MAR01352Inferred only
a 1,2-diacyl-sn-glycero-3-phosphate is a substrate of LPIN3CompoundRhea RHEA:27429Inferred only
phosphatidic acid is a substrate of LPIN3CompoundHuman-GEM MAR00598Inferred only
phosphatidic acid is a substrate of LPIN3CompoundHuman-GEM MAR00602Inferred only
phosphatidic acid is a substrate of LPIN3CompoundHuman-GEM MAR00597Inferred only
phosphatidic acid is a substrate of LPIN3CompoundHuman-GEM MAR00601Inferred only
phosphatidic acid is a substrate of LPIN3CompoundHuman-GEM MAR00596Inferred only
phosphatidic acid is a substrate of LPIN3CompoundHuman-GEM MAR00600Inferred only
phosphatidic acid is a substrate of LPIN3CompoundHuman-GEM MAR00599Inferred only
sphingosine 1-phosphate is a substrate of LPIN3CompoundHuman-GEM MAR00775Inferred only

Reactions

12 reactions

water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00596

Other names

3 names

Resolves to: LPIN3

Also called: Lipin-3Lipin-3-likeLIPN3L

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CC BY 4.0

Reference data

water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)

Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4

Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol

Human-GEM MAR00597CC BY 4.0Reference data

water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)

Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4

Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol

Human-GEM MAR00598CC BY 4.0Reference data

water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)

Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4

Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol

Human-GEM MAR00599CC BY 4.0Reference data

water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)

Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4

Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol

Human-GEM MAR00600CC BY 4.0Reference data

water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)

Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4

Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol

Human-GEM MAR00601CC BY 4.0Reference data

water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)

Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4

Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol

Human-GEM MAR00602CC BY 4.0Reference data

MAM01431c+wateran N-acylsphing-4-enine+phosphate(3-)

Catalysed by PLPP1 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4

Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol

Human-GEM MAR00767CC BY 4.0Reference data

water+sphingosine 1-phosphatephosphate(3-)+sphing-4-enine

Catalysed by PLPP1 or LPIN2 or LPIN3 or PLPP2 or PLPP3 or SGPP2

Reaction pageLeft to rightBalancedEC 3.1.3.4cytosol

Human-GEM MAR00775CC BY 4.0Reference data

2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate+water2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol+phosphate(3-)

Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4

Reaction pageReversibleBalancedEC 3.1.3.4cytosol

Human-GEM MAR01352CC BY 4.0Reference data

MAM00628c+water1-O-alkyl-2-acyl-sn-glycerol+phosphate(3-)

Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4

Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol

Human-GEM MAR07598CC BY 4.0Reference data

a 1,2-diacyl-sn-glycero-3-phosphate+watera 1,2-diacyl-sn-glycerol+hydrogenphosphate

Catalysed by PLPP1 or PLPP3 or PLPP2 or LPIN1 or PLPP4 or PLPP5 or LPIN2 or LPIN3

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:27429CC BY 4.0Reference data