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Proteins/UNIPROT:Q9Y530
ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose. Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins. Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively..
Function from UniProtKB (Q9Y530), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
30 statements
30 statements · 4 reference databases · Subject: OARD1 · Sources: Bgee, Hetionet, Human-GEM, Rhea
8 reactions
2water+MAM02866cL-glutamate(1-)+glycine+MAM02867c
Catalysed by SIRT6 or SIRT1 or SIRT5 or OARD1 or ACY3 or MACROD1 or SIRT3 or NTAQ1 or NTAN1 or SIRT7
Reaction pageReversibleBalancedEC 3.5.1.-cytosol
Human-GEM MAR05336CC BY 4.0Reference data
5 names
Resolves to: OARD1
water+MAM02548cacetate+MAM02867c
Catalysed by SIRT2 or SIRT6 or SIRT1 or SIRT5 or OARD1 or ACY3 or MACROD1 or NAAA or SIRT3 or NTAN1 or MACROD2 or SIRT7
Reaction pageReversibleBalancedEC 3.5.1.-cytosol
Human-GEM MAR05339CC BY 4.0Reference data
water+MAM02867cammonium+MAM02865c
Catalysed by SIRT2 or SIRT6 or SIRT1 or SIRT5 or OARD1 or ACY3 or NTAQ1 or NTAN1 or SIRT7
Reaction pageLeft to rightBalancedEC 3.5.1.-cytosol
Human-GEM MAR05340CC BY 4.0Reference data
water+2''-O-acetyl-ADP-D-riboseacetate+ADP-D-ribose+proton
Catalysed by MACROD2 or MACROD1 or OARD1
Reaction pageLeft to rightBalancedEC 3.1.1.106nucleus
Human-GEM MAR20099CC BY 4.0Reference data
water+alpha-NAD(+)ADP-D-ribose+proton+nicotinamide
Catalysed by MACROD2 or MACROD1 or OARD1
Reaction pageLeft to rightBalancedEC 3.1.1.106nucleus
Human-GEM MAR20100CC BY 4.0Reference data
2''-O-acetyl-ADP-D-ribose+waterADP-D-ribose+acetate+hydron
Catalysed by MACROD2 or MACROD1 or OARD1
Reaction pageLeft to rightBalanced
Rhea RHEA:57060CC BY 4.0Reference data
5-O-(ADP-D-ribosyl)-L-glutamyl-[protein]+waterL-glutamyl-[protein]+ADP-D-ribose+hydron
Catalysed by MACROD2 or MACROD1 or OARD1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:58248CC BY 4.0Reference data
alpha-NAD(+)+waterADP-D-ribose+nicotinamide+hydron
Catalysed by MACROD2 or ADPRH or MACROD1 or ADPRS or OARD1
Reaction pageDirection not assertedBalanced
Rhea RHEA:68792CC BY 4.0Reference data