Proteins/UNIPROT:P08779

KRT16

ProteinUNIPROT:P08779

Structural component of intermediate filaments in epithelial keratinocytes. Forms heteropolymers with type II keratins KRT6A and KRT6B, assembling into keratin intermediate filament networks that contribute to cytoskeletal resilience of palm, sole, nail bed and oral mucosa. Regulates epidermal innate immunity and inflammatory signaling in response to barrier disruption. Required for normal palmoplantar epidermal differentiation and nail unit structure (By similarity)..

Function from UniProtKB (P08779), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

4 rows

isolated focal non-epidermolytic palmoplantar keratoderma has a germline basis in KRT16DiseaseGenCC HGNC:6423|MONDO:0014622Inferred only
pachyonychia congenita has a germline basis in KRT16DiseaseGenCC HGNC:6423|MONDO:0016471Inferred only
pachyonychia congenita 1 has a germline basis in KRT16DiseaseGenCC HGNC:6423|MONDO:0008173Inferred only
palmoplantar keratoderma, nonepidermolytic, focal 1 has a germline basis in KRT16DiseaseGenCC HGNC:6423|MONDO:0013073Inferred only

Statements

26 statements

26 statements · 4 reference databases · Subject: KRT16 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

KRT16 covaries with KRT77ProteinHetionet hetionet:covaries:374454-3868Inferred only
KRT16 covaries with PPP1R12BProteinHetionet hetionet:covaries:3868-4660Inferred only
KRT16 interacts with CAND1ProteinHetionet hetionet:interacts:3868-55832Inferred only
KRT16 interacts with COPS5ProteinHetionet hetionet:interacts:10987-3868Inferred only
KRT16 interacts with CUL1ProteinHetionet hetionet:interacts:3868-8454Inferred only
KRT16 interacts with CUL2ProteinHetionet hetionet:interacts:3868-8453Inferred only
KRT16 interacts with CUL3ProteinHetionet hetionet:interacts:3868-8452Inferred only
EGR1 interacts with KRT16ProteinHetionet hetionet:interacts:1958-3868Inferred only
KRT16 interacts with EIF4A3ProteinHetionet hetionet:interacts:3868-9775Inferred only
ESR1 interacts with KRT16ProteinHetionet hetionet:interacts:2099-3868Inferred only
KRT16 interacts with IQCB1ProteinHetionet hetionet:interacts:3868-9657Inferred only
ITGA4 interacts with KRT16ProteinHetionet hetionet:interacts:3676-3868Inferred only

Show the remaining 14

KRT16 interacts with NEDD8ProteinHetionet hetionet:interacts:3868-4738Inferred only
KRT16 interacts with TCHPProteinHetionet hetionet:interacts:3868-84260Inferred only
KRT16 interacts with UBCProteinHetionet hetionet:interacts:3868-7316Inferred only
KRT16 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
KRT16 participates in Formation of the cornified envelopePathwayReactome R-HSA-6809371Inferred only
KRT16 participates in KeratinizationPathwayReactome R-HSA-6805567Inferred only
KRT16 participates in Vitamin D receptor pathwayPathwayWikiPathways WP2877Inferred only
KRT16 regulates negative regulation of cell migrationBiological processgene ontology P08779|GO:0030336Inferred only
HDAC6 increases the expression of KRT16ProteinHetionet hetionet:regulates:10013-3868Inferred only
PLPP1 increases the expression of KRT16ProteinHetionet hetionet:regulates:8611-3868Inferred only
PRMT7 increases the expression of KRT16ProteinHetionet hetionet:regulates:54496-3868Inferred only
RPS6KA2 increases the expression of KRT16ProteinHetionet hetionet:regulates:6196-3868Inferred only
SMARCE1 increases the expression of KRT16ProteinHetionet hetionet:regulates:6605-3868Inferred only
UGCG decreases the expression of KRT16ProteinHetionet hetionet:regulates:7357-3868Inferred only

Other names

5 names

Resolves to: KRT16

Also called: CK-16Cytokeratin-16K16Keratin-16KRT16A

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