Loading the page.
Proteins/UNIPROT:Q8IWX5
Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling. Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (By similarity)..
Function from UniProtKB (Q8IWX5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
21 statements
21 statements · 6 reference databases · Subject: SGPP2 · Sources: Bgee, gene ontology, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
water+sphingosine 1-phosphatephosphate(3-)+sphing-4-enine
Catalysed by PLPP1 or LPIN2 or LPIN3 or PLPP2 or PLPP3 or SGPP2
Reaction pageLeft to rightBalancedEC 3.1.3.4cytosol
Human-GEM MAR00775CC BY 4.0Reference data
4 names
Resolves to: SGPP2
Reaction pageLeft to rightBalanced
Rhea RHEA:27514CC BY 4.0Reference data
sphing-4-enine 1-phosphate+watersphing-4-enine+hydrogenphosphate
Catalysed by PLPP1 or PLPP3 or PLPP2 or SGPP2 or SGPP1
Reaction pageLeft to rightBalanced
Rhea RHEA:27518CC BY 4.0Reference data
(4R)-hydroxysphinganine 1-phosphate+water(4R)-hydroxysphinganine+hydrogenphosphate
Catalysed by SGPP2
Reaction pageLeft to rightBalanced
Rhea RHEA:33067CC BY 4.0Reference data