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Proteins/UNIPROT:Q16854
Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (By similarity). Widely used as target of antiviral and chemotherapeutic agents..
Function from UniProtKB (Q16854), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
29 statements
29 statements · 6 reference databases · Subject: DGUOK · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
ATP+2'-deoxyguanosineADP+dGMP+proton
Catalysed by DGUOK
Reaction pageLeft to rightBalancedEC 2.7.1.113cytosol
Human-GEM MAR04600CC BY 4.0Reference data
ATP+2'-deoxyguanosineADP+dGMP+proton
Catalysed by DGUOK
2 names
Resolves to: DGUOK
Human-GEM MAR04601CC BY 4.0Reference data
2'-deoxyguanosine+ATP(4-)dGMP+ADP(3-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:19201CC BY 4.0Reference data
2'-deoxyadenosine+ATP(4-)CHEBI:58245+ADP(3-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:23452CC BY 4.0Reference data