Loading the page.
Proteins/UNIPROT:Q14693
Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels. Is involved in adipocyte differentiation (By similarity). Recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity). Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression (By similarity)..
Function from UniProtKB (Q14693), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
92 statements
92 statements · 8 reference databases · Subject: LPIN1 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
25 reactions
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
2 names
Resolves to: LPIN1
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00597CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00598CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00599CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00600CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00601CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00602CC BY 4.0Reference data
MAM01431c+wateran N-acylsphing-4-enine+phosphate(3-)
Catalysed by PLPP1 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00767CC BY 4.0Reference data
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate+water2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageReversibleBalancedEC 3.1.3.4cytosol
Human-GEM MAR01352CC BY 4.0Reference data
MAM00628c+water1-O-alkyl-2-acyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR07598CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphate+watera 1,2-diacyl-sn-glycerol+hydrogenphosphate
Catalysed by PLPP1 or PLPP3 or PLPP2 or LPIN1 or PLPP4 or PLPP5 or LPIN2 or LPIN3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:27429CC BY 4.0Reference data
CHEBI:82921+waterCHEBI:41847+hydrogenphosphate
Catalysed by LPIN1
Reaction pageLeft to rightBalanced
Rhea RHEA:33335CC BY 4.0Reference data