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Proteins/UNIPROT:O94905

ERLIN2

Protein·UNIPROT:O94905

Open in the graph

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex..

Function from UniProtKB (O94905), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

5 rows

hereditary spastic paraplegia 18 has a germline basis in ERLIN2DiseaseGenCC HGNC:1356|MONDO:0012639Inferred only
juvenile primary lateral sclerosis has a germline basis in ERLIN2DiseaseGenCC HGNC:1356|MONDO:0011663Inferred only
recessive intellectual disability-motor dysfunction-multiple joint contractures syndrome has a germline basis in ERLIN2DiseaseGenCC HGNC:1356|MONDO:0017232Inferred only
spastic paraplegia 18a, autosomal dominant has a germline basis in ERLIN2DiseaseGenCC HGNC:1356|MONDO:0957788Inferred only
spastic paraplegia 18b, autosomal recessive has a germline basis in ERLIN2DiseaseGenCC HGNC:1356|MONDO:0700309Inferred only

Statements

25 statements

25 statements · 3 reference databases · Subject: ERLIN2 · Sources: gene ontology, Hetionet, Reactome

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ERLIN2 participates in ABC transporter disordersPathwayReactome R-HSA-5619084Inferred only
ERLIN2 participates in ABC-family protein mediated transportPathwayReactome R-HSA-382556Inferred only
ERLIN2 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
ERLIN2 participates in AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)PathwayReactome R-HSA-9931269Inferred only
ERLIN2 participates in Co-inhibition by PD-1PathwayReactome R-HSA-389948Inferred only
ERLIN2 participates in Defective CFTR causes cystic fibrosisPathwayReactome R-HSA-5678895Inferred only
ERLIN2 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
ERLIN2 participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
ERLIN2 participates in Disorders of transmembrane transportersPathwayReactome R-HSA-5619115Inferred only
ERLIN2 participates in FGFR1 mutant receptor activationPathwayReactome R-HSA-1839124Inferred only
ERLIN2 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
ERLIN2 participates in Regulation of PD-L1(CD274) expressionPathwayReactome R-HSA-9909648Inferred only

Show the remaining 13

ERLIN2 participates in Regulation of PD-L1(CD274) Post-translational modificationPathwayReactome R-HSA-9909615Inferred only
ERLIN2 participates in Regulation of T cell activation by CD28 familyPathwayReactome R-HSA-388841Inferred only
ERLIN2 participates in Signaling by FGFR in diseasePathwayReactome R-HSA-1226099Inferred only
ERLIN2 participates in Signaling by FGFR1 in diseasePathwayReactome R-HSA-5655302Inferred only
ERLIN2 participates in Signaling by plasma membrane FGFR1 fusionsPathwayReactome R-HSA-8853336Inferred only
ERLIN2 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
ERLIN2 regulates negative regulation of cholesterol biosynthetic processBiological processgene ontology O94905|GO:0045541Inferred only
ERLIN2 regulates negative regulation of fatty acid biosynthetic processBiological processgene ontology O94905|GO:0045717Inferred only
ERLIN2 regulates regulation of cholesterol biosynthetic processBiological processgene ontology O94905|GO:0045540Inferred only
EDN1 decreases the expression of ERLIN2ProteinHetionet hetionet:regulates:1906-11160Inferred only
EIF4EBP1 decreases the expression of ERLIN2ProteinHetionet hetionet:regulates:1978-11160Inferred only
PDS5A decreases the expression of ERLIN2ProteinHetionet hetionet:regulates:23244-11160Inferred only
PLPP1 decreases the expression of ERLIN2ProteinHetionet hetionet:regulates:8611-11160Inferred only

Other names

5 names

Resolves to: ERLIN2

Also called: C8orf2Endoplasmic reticulum lipid raft-associated protein 2SPFH domain-containing protein 2SPFH2Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2

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