Proteins/UNIPROT:Q6ZMZ0

RNF19B

ProteinUNIPROT:Q6ZMZ0

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death..

Function from UniProtKB (Q6ZMZ0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

27 statements

27 statements · 3 reference databases · Subject: RNF19B · Sources: Hetionet, Reactome, WikiPathways

Order

RNF19B covaries with ENTPD2ProteinHetionet hetionet:covaries:127544-954Inferred only
HSP90AB1 interacts with RNF19BProteinHetionet hetionet:interacts:127544-3326Inferred only
PPP1CC interacts with RNF19BProteinHetionet hetionet:interacts:127544-5501Inferred only
UBE2L3 interacts with RNF19BProteinHetionet hetionet:interacts:127544-7332Inferred only
UBE2L6 interacts with RNF19BProteinHetionet hetionet:interacts:127544-9246Inferred only
UCKL1 interacts with RNF19BProteinHetionet hetionet:interacts:127544-54963Inferred only
RNF19B participates in 22q11 2 distal CNVPathwayWikiPathways WP5546Inferred only
RNF19B participates in Activation of STAT3 by cadherin engagementPathwayReactome R-HSA-9958825Inferred only
RNF19B participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
RNF19B participates in Adherens junctions interactionsPathwayReactome R-HSA-418990Inferred only
RNF19B participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only
RNF19B participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only

Show the remaining 15

RNF19B participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
RNF19B participates in Cell-cell junction organizationPathwayReactome R-HSA-421270Inferred only
RNF19B participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
RNF19B participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
RNF19B increases the expression of AGR2ProteinHetionet hetionet:regulates:127544-10551Inferred only
AKAP8L increases the expression of RNF19BProteinHetionet hetionet:regulates:26993-127544Inferred only
CLCN3 increases the expression of RNF19BProteinHetionet hetionet:regulates:1182-127544Inferred only
GATA3 increases the expression of RNF19BProteinHetionet hetionet:regulates:2625-127544Inferred only
PHF2 increases the expression of RNF19BProteinHetionet hetionet:regulates:5253-127544Inferred only
PLPP1 increases the expression of RNF19BProteinHetionet hetionet:regulates:8611-127544Inferred only
RPS27A increases the expression of RNF19BProteinHetionet hetionet:regulates:6233-127544Inferred only
SOAT1 increases the expression of RNF19BProteinHetionet hetionet:regulates:6646-127544Inferred only
TRAM2 increases the expression of RNF19BProteinHetionet hetionet:regulates:9697-127544Inferred only
UGCG increases the expression of RNF19BProteinHetionet hetionet:regulates:7357-127544Inferred only
ZMYM2 increases the expression of RNF19BProteinHetionet hetionet:regulates:7750-127544Inferred only

Reactions

1 reaction

MAM00204c+ATP+MAM03105cMAM00214c+AMP+diphosphate(3-)
Catalysed by RNF40 & RNF20 or SAE1 & UBA2 or RING1 & RNF2 or HECW1 or MYCBP2 or MYLIP or UBE3C or RNF216 or UBR7 or RNF14 or UBR2

Other names

5 names

Resolves to: RNF19B

Also called: IBR domain-containing protein 3IBRDC3Natural killer lytic-associated moleculeNKLAMRING finger protein 19B

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