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Proteins/UNIPROT:Q8NEB5
Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate. Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules..
Function from UniProtKB (Q8NEB5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
47 statements
47 statements · 5 reference databases · Subject: PLPP5 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
15 reactions
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
4 names
Resolves to: PLPP5
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00597CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00598CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00599CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00600CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00601CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00602CC BY 4.0Reference data
MAM01431c+wateran N-acylsphing-4-enine+phosphate(3-)
Catalysed by PLPP1 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00767CC BY 4.0Reference data
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate+water2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageReversibleBalancedEC 3.1.3.4cytosol
Human-GEM MAR01352CC BY 4.0Reference data
MAM00628c+water1-O-alkyl-2-acyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR07598CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphate+watera 1,2-diacyl-sn-glycerol+hydrogenphosphate
Catalysed by PLPP1 or PLPP3 or PLPP2 or LPIN1 or PLPP4 or PLPP5 or LPIN2 or LPIN3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:27429CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol 3-diphosphate+watera 1,2-diacyl-sn-glycero-3-phosphate+hydrogenphosphate+hydron
Catalysed by PLPP1 or PLPP4 or PLPP5
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:27449CC BY 4.0Reference data