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Proteins/UNIPROT:Q92539
Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism..
Function from UniProtKB (Q92539), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
60 statements
60 statements · 9 reference databases · Subject: LPIN2 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
11 reactions
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
2 names
Resolves to: LPIN2
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00597CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00598CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00599CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00600CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00601CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00602CC BY 4.0Reference data
water+sphingosine 1-phosphatephosphate(3-)+sphing-4-enine
Catalysed by PLPP1 or LPIN2 or LPIN3 or PLPP2 or PLPP3 or SGPP2
Reaction pageLeft to rightBalancedEC 3.1.3.4cytosol
Human-GEM MAR00775CC BY 4.0Reference data
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate+water2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageReversibleBalancedEC 3.1.3.4cytosol
Human-GEM MAR01352CC BY 4.0Reference data
MAM00628c+water1-O-alkyl-2-acyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR07598CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphate+watera 1,2-diacyl-sn-glycerol+hydrogenphosphate
Catalysed by PLPP1 or PLPP3 or PLPP2 or LPIN1 or PLPP4 or PLPP5 or LPIN2 or LPIN3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:27429CC BY 4.0Reference data