Loading the page.
Proteins/UNIPROT:O95154
Catalyzes the NADPH-dependent reduction of various carbonyl-containing compounds, including aldehydes, ketones, and toxic products from cellular metabolism or environmental exposure. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates, thus preventing the formation of protein adducts that contribute to AFB1-induced toxicity..
Function from UniProtKB (O95154), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
42 statements
42 statements · 4 reference databases · Subject: AKR7A3 · Sources: Hetionet, Reactome, Rhea, WikiPathways
8 reactions
MAM01294c+2protonMAM00229c
Reaction pageLeft to rightUnbalancedEC 1.1.1.11cytosol
Human-GEM MAR07025CC BY 4.0Reference data
MAM00229c+3protonMAM01156c
Reaction pageLeft to rightUnbalancedEC 1.1.1.11cytosol
Human-GEM MAR07026CC BY 4.0Reference data
4 names
Resolves to: AKR7A3
MAM01294c+2protonMAM01318c
Reaction pageLeft to rightUnbalancedEC 1.1.1.11cytosol
Human-GEM MAR07027CC BY 4.0Reference data
MAM01318c+3protonMAM01156c
Reaction pageLeft to rightUnbalancedEC 1.1.1.11cytosol
Human-GEM MAR07028CC BY 4.0Reference data
CHEBI:15734+NADP(3-)an aldehyde+NADPH(4-)+hydron
Catalysed by AKR7A3 or AKR1A1 or CBR1 or KCNAB1
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:15937CC BY 4.0Reference data
CHEBI:133967+NADPH(4-)+hydronCHEBI:233587+NADP(3-)
Catalysed by AKR7A3
Reaction pageLeft to rightBalanced
Rhea RHEA:84055CC BY 4.0Reference data
CHEBI:133967+NADPH(4-)+hydronCHEBI:233588+NADP(3-)
Catalysed by AKR7A3
Reaction pageLeft to rightBalanced
Rhea RHEA:84059CC BY 4.0Reference data
CHEBI:233587+NADPH(4-)+2hydronCHEBI:53108+NADP(3-)
Catalysed by AKR7A3
Reaction pageLeft to rightBalanced
Rhea RHEA:84063CC BY 4.0Reference data