Proteins/UNIPROT:A1L0T0

HACL2

ProteinUNIPROT:A1L0T0

Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway..

Function from UniProtKB (A1L0T0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

18 statements

18 statements · 3 reference databases · Subject: HACL2 · Sources: Hetionet, Rhea, UniProt

Order

ADH6 covaries with HACL2ProteinHetionet hetionet:covaries:10994-130Inferred only
MX2 covaries with HACL2ProteinHetionet hetionet:covaries:10994-4600Inferred only
NTSR1 covaries with HACL2ProteinHetionet hetionet:covaries:10994-4923Inferred only
ATXN1 interacts with HACL2ProteinHetionet hetionet:interacts:10994-6310Inferred only
CUL3 interacts with HACL2ProteinHetionet hetionet:interacts:10994-8452Inferred only
ECT2 interacts with HACL2ProteinHetionet hetionet:interacts:10994-1894Inferred only
HACL2 interacts with MMS19ProteinHetionet hetionet:interacts:10994-64210Inferred only
MYC interacts with HACL2ProteinHetionet hetionet:interacts:10994-4609Inferred only
TOM1 interacts with HACL2ProteinHetionet hetionet:interacts:10043-10994Inferred only
UBC interacts with HACL2ProteinHetionet hetionet:interacts:10994-7316Inferred only
UBL4A interacts with HACL2ProteinHetionet hetionet:interacts:10994-8266Inferred only
XRCC6 interacts with HACL2ProteinHetionet hetionet:interacts:10994-2547Inferred only

Show the remaining 6

PCK2 decreases the expression of HACL2ProteinHetionet hetionet:regulates:5106-10994Inferred only
RBM34 decreases the expression of HACL2ProteinHetionet hetionet:regulates:23029-10994Inferred only
VRK3 increases the expression of HACL2ProteinHetionet hetionet:regulates:51231-10994Inferred only
HACL2 requires the cofactor magnesium(2+)CompoundUniProt A1L0T0Inferred only
HACL2 requires the cofactor thiamine diphosphateCompoundUniProt A1L0T0Inferred only
2-hydroxyoctadecanoyl-CoA is a substrate of HACL2CompoundRhea RHEA:55196Inferred only

Reactions

2 reactions

2-hydroxyoctadecanoyl-CoACHEBI:138631+CHEBI:57376
Catalysed by HACL2 or HACL1
Reaction pageLeft to rightBalanced
Rhea RHEA:55196CC BY 4.0Reference data
CHEBI:138654CHEBI:17302+CHEBI:57376
Catalysed by HACL2
Reaction pageLeft to rightBalanced
Rhea RHEA:55212CC BY 4.0Reference data

Other names

4 names

Resolves to: HACL2

Also called: Acetolactate synthase-like proteinAHASIlvB-like proteinILVBL

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