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Proteins/UNIPROT:Q9Y644
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis..
Function from UniProtKB (Q9Y644), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
227 statements
227 statements · 7 reference databases · Subject: RFNG · Sources: Bgee, gene ontology, Hetionet, Reactome, Rhea, UniProt, WikiPathways
2 reactions
3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein]+UDP-N-acetyl-alpha-D-glucosamine3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein]+UDP+hydron
Catalysed by MFNG or LFNG or RFNG
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:70511CC BY 4.0Reference data
3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein]+UDP-N-acetyl-alpha-D-glucosamine3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein]
1 name
Resolves to: RFNG
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:70531CC BY 4.0Reference data