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Proteins/UNIPROT:Q9UKY4
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins..
Function from UniProtKB (Q9UKY4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
7 rows
37 statements
37 statements · 2 reference databases · Subject: POMT2 · Sources: Hetionet, Reactome
3 reactions
MAM01733c+proton+MAM02645cMAM00205c+MAM01734c
Reaction pageReversibleBalance undeterminableEC 2.4.1.109cytosol
Human-GEM MAR08378CC BY 4.0Reference data
a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate+L-seryl-[protein]3-O-(alpha-D-mannosyl)-L-seryl-[protein]+a di-trans,poly-cis-dolichyl phosphate+hydron
1 name
Resolves to: POMT2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:17377CC BY 4.0Reference data
a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate+L-threonyl-[protein]3-O-(alpha-D-mannosyl)-L-threonyl-[protein]+a di-trans,poly-cis-dolichyl phosphate+hydron
Catalysed by TMTC3 or TMTC1 or TMTC2 or TMEM260 or POMT2 or POMT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:53396CC BY 4.0Reference data