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Proteins/UNIPROT:P55789
[Isoform 1]: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen..
[Isoform 2]: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.
Function from UniProtKB (P55789), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
27 statements
27 statements · 4 reference databases · Subject: GFER · Sources: Hetionet, Reactome, UniProt, WikiPathways
2 reactions
2CHEBI:16520+dioxygenCHEBI:17412+hydrogen peroxide
Catalysed by QSOX1 or GFER or QSOX2 or ERO1B or ERO1A
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:17357CC BY 4.0Reference data
[protein]-dithiol+dioxygen[protein]-disulfide+hydrogen peroxide
Catalysed by GFER or
5 names
Resolves to: GFER
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:59116CC BY 4.0Reference data