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Proteins/UNIPROT:P85299

PRR5

Protein·UNIPROT:P85299

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Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer..

Function from UniProtKB (P85299), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

45 statements

45 statements · 4 reference databases · Subject: PRR5 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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MTOR interacts with PRR5ProteinHetionet hetionet:interacts:2475-55615Inferred only
UBC interacts with PRR5ProteinHetionet hetionet:interacts:55615-7316Inferred only
PRR5 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
PRR5 participates in CD28 dependent PI3K/Akt signalingPathwayReactome R-HSA-389357Inferred only
PRR5 participates in Cellular responses to mechanical stimuliPathwayReactome R-HSA-9855142Inferred only
PRR5 participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
PRR5 participates in Co-stimulation by CD28PathwayReactome R-HSA-389356Inferred only
PRR5 participates in Constitutive Signaling by AKT1 E17K in CancerPathwayReactome R-HSA-5674400Inferred only
PRR5 participates in Dengue Virus InfectionPathwayReactome R-HSA-9839923Inferred only
PRR5 participates in Dengue virus modulates apoptosisPathwayReactome R-HSA-9920951Inferred only
PRR5 participates in Dengue Virus-Host InteractionsPathwayReactome R-HSA-9918481Inferred only
PRR5 participates in DiseasePathwayReactome R-HSA-1643685Inferred only

Show the remaining 33

PRR5 participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
PRR5 participates in Dravet syndromePathwayWikiPathways WP5200Inferred only
PRR5 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
PRR5 participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
PRR5 participates in High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cellsPathwayReactome R-HSA-9856530Inferred only
PRR5 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
PRR5 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
PRR5 participates in Intracellular signaling by second messengersPathwayReactome R-HSA-9006925Inferred only
PRR5 participates in PI3K/AKT Signaling in CancerPathwayReactome R-HSA-2219528Inferred only
PRR5 participates in PIP3 activates AKT signalingPathwayReactome R-HSA-1257604Inferred only
PRR5 participates in Regulation of T cell activation by CD28 familyPathwayReactome R-HSA-388841Inferred only
PRR5 participates in Regulation of TP53 ActivityPathwayReactome R-HSA-5633007Inferred only
PRR5 participates in Regulation of TP53 DegradationPathwayReactome R-HSA-6804757Inferred only
PRR5 participates in Regulation of TP53 Expression and DegradationPathwayReactome R-HSA-6806003Inferred only
PRR5 participates in Response of endothelial cells to shear stressPathwayReactome R-HSA-9860931Inferred only
PRR5 participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
PRR5 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
PRR5 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
PRR5 participates in Signaling by VEGFPathwayReactome R-HSA-194138Inferred only
PRR5 participates in Target of rapamycin signalingPathwayWikiPathways WP1471Inferred only
PRR5 participates in Transcriptional Regulation by TP53PathwayReactome R-HSA-3700989Inferred only
PRR5 participates in VEGFA-VEGFR2 PathwayPathwayReactome R-HSA-4420097Inferred only
PRR5 participates in VEGFR2 mediated vascular permeabilityPathwayReactome R-HSA-5218920Inferred only
PRR5 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
PRR5 regulates negative regulation of apoptotic processBiological processgene ontology P85299|GO:0043066Inferred only
PRR5 regulates positive regulation of cell growthBiological processgene ontology P85299|GO:0030307Inferred only
FCHO1 decreases the expression of PRR5ProteinHetionet hetionet:regulates:23149-55615Inferred only
MRPS16 increases the expression of PRR5ProteinHetionet hetionet:regulates:51021-55615Inferred only
NR3C1 increases the expression of PRR5ProteinHetionet hetionet:regulates:2908-55615Inferred only
PCK2 decreases the expression of PRR5ProteinHetionet hetionet:regulates:5106-55615Inferred only
POLR2H increases the expression of PRR5ProteinHetionet hetionet:regulates:5437-55615Inferred only
TIMP2 decreases the expression of PRR5ProteinHetionet hetionet:regulates:7077-55615Inferred only
TRIM62 increases the expression of PRR5ProteinHetionet hetionet:regulates:55223-55615Inferred only

Other names

4 names

Resolves to: PRR5

Also called: observed with Rictor-1Protein observed with Rictor-1Protor-1PROTOR1

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