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Proteins/UNIPROT:Q9Y2Q0
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:CDC50A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the cell membrane (By similarity). Acts as aminophospholipid translocase at the cell membrane in neuronal cells (By similarity)..
Function from UniProtKB (Q9Y2Q0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
85 statements
85 statements · 9 reference databases · Subject: ATP8A1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
5 reactions
ATP+water+phosphatidylethanolamineADP+proton+phosphatidylethanolamine+phosphate(3-)
Transported by ABCB4 or ATP8A1 or ATP10A
Reaction pageLeft to rightBalance undeterminableEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR01594CC BY 4.0Reference data
4 names
Resolves to: ATP8A1
Reaction pageLeft to rightBalance undeterminableEC 7.6.2.1cytosol, mitochondrial matrix
Human-GEM MAR01596CC BY 4.0Reference data
ATP+water+phosphatidyl-L-serineADP+proton+phosphate(3-)+phosphatidyl-L-serine
Transported by ATP8A1 or ATP10A
Reaction pageLeft to rightBalance undeterminablecytosol, extracellular space
Human-GEM MAR01661CC BY 4.0Reference data
ATP+water+phosphatidyl-L-serineADP+proton+phosphate(3-)+phosphatidyl-L-serine
Transported by ATP8A1 or ATP10A
Reaction pageLeft to rightBalance undeterminablecytosol, mitochondrial matrix
Human-GEM MAR01664CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-L-serine+ATP(4-)+watera 1,2-diacyl-sn-glycero-3-phospho-L-serine+ADP(3-)+hydrogenphosphate+hydron
Transported by ATP8B1 or ATP8B3 or ABCA1 or ATP11A or ABCA7 or ATP11C or ATP8A2 or ATP11B or ATP8A1
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38567CC BY 4.0Reference data