Proteins/UNIPROT:Q8TCX1

DYNC2LI1

ProteinUNIPROT:Q8TCX1

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles. Involved in the regulation of ciliary length..

Function from UniProtKB (Q8TCX1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

Ellis-van Creveld syndrome has a germline basis in DYNC2LI1DiseaseGenCC HGNC:24595|MONDO:0009162Inferred only
Jeune syndrome has a germline basis in DYNC2LI1DiseaseGenCC HGNC:24595|MONDO:0018770Inferred only
short-rib thoracic dysplasia 15 with polydactyly has a germline basis in DYNC2LI1DiseaseGenCC HGNC:24595|MONDO:0014907Inferred only

Statements

27 statements

27 statements · 4 reference databases · Subject: DYNC2LI1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

BAG3 interacts with DYNC2LI1ProteinHetionet hetionet:interacts:51626-9531Inferred only
SOD1 interacts with DYNC2LI1ProteinHetionet hetionet:interacts:51626-6647Inferred only
UBC interacts with DYNC2LI1ProteinHetionet hetionet:interacts:51626-7316Inferred only
DYNC2LI1 participates in 3q29 copy number variation syndromePathwayWikiPathways WP4906Inferred only
DYNC2LI1 participates in Assembly of the 9+0 primary ciliumPathwayReactome R-HSA-9975921Inferred only
DYNC2LI1 participates in Bardet Biedl syndromePathwayWikiPathways WP5234Inferred only
DYNC2LI1 participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
DYNC2LI1 participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
DYNC2LI1 participates in Genes related to primary cilium development based on CRISPR PathwayWikiPathways WP4536Inferred only
DYNC2LI1 participates in Intraflagellar transportPathwayReactome R-HSA-5620924Inferred only
DYNC2LI1 participates in Intraflagellar transport proteins binding to dyneinPathwayWikiPathways WP4532Inferred only
DYNC2LI1 participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only

Show the remaining 15

DYNC2LI1 participates in Vasopressin regulated water reabsorptionPathwayWikiPathways WP5085Inferred only
DYNC2LI1 regulates regulation of cilium assemblyBiological processgene ontology Q8TCX1|GO:1902017Inferred only
COQ8A increases the expression of DYNC2LI1ProteinHetionet hetionet:regulates:56997-51626Inferred only
FBXO7 increases the expression of DYNC2LI1ProteinHetionet hetionet:regulates:25793-51626Inferred only
GALE increases the expression of DYNC2LI1ProteinHetionet hetionet:regulates:2582-51626Inferred only
IARS2 increases the expression of DYNC2LI1ProteinHetionet hetionet:regulates:55699-51626Inferred only
KAT6A increases the expression of DYNC2LI1ProteinHetionet hetionet:regulates:7994-51626Inferred only
MECP2 increases the expression of DYNC2LI1ProteinHetionet hetionet:regulates:4204-51626Inferred only
NUCKS1 increases the expression of DYNC2LI1ProteinHetionet hetionet:regulates:64710-51626Inferred only
PDHX increases the expression of DYNC2LI1ProteinHetionet hetionet:regulates:8050-51626Inferred only
PHKB increases the expression of DYNC2LI1ProteinHetionet hetionet:regulates:5257-51626Inferred only
RAD9A increases the expression of DYNC2LI1ProteinHetionet hetionet:regulates:5883-51626Inferred only
TBC1D31 increases the expression of DYNC2LI1ProteinHetionet hetionet:regulates:93594-51626Inferred only
TNIP1 increases the expression of DYNC2LI1ProteinHetionet hetionet:regulates:10318-51626Inferred only
YKT6 increases the expression of DYNC2LI1ProteinHetionet hetionet:regulates:10652-51626Inferred only

Other names

4 names

Resolves to: DYNC2LI1

Also called: Cytoplasmic dynein 2 light intermediate chain 1D2LICDynein 2 light intermediate chainLIC3

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