PLAUR

GPI-anchored receptor that recruits and activates the urokinase-type plasminogen activator (uPA) at the cell surface. Activated uPA converts plasminogen into plasmin, initiating extracellular matrix degradation and remodeling. Also binds the extracellular matrix protein vitronectin, promoting cell-matrix adhesion and indirectly integrin signaling. This dual interaction coordinates dynamic changes in cell migration, proliferation, and tissue remodeling..

Function from UniProtKB (Q03405), read 2026-09-23. CC BY 4.0.