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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:O14791

APOL1

Protein·UNIPROT:O14791

Open in the graph

May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. A component of trypanosome lytic factor of human serum; plays a crucial role in killing Trypanosoma brucei by forming pores in parasite lysosomal membranes and sensitizing T.brucei to oxidation-stimulated osmotic lysis..

Function from UniProtKB (O14791), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

focal segmental glomerulosclerosis 4, susceptibility to has a germline basis in APOL1DiseaseGenCC HGNC:618|MONDO:0012931Inferred only

Statements

18 statements

18 statements · 3 reference databases · Subject: APOL1 · Sources: Hetionet, Reactome, WikiPathways

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APOA1 interacts with APOL1ProteinHetionet hetionet:interacts:335-8542Inferred only
APOL1 participates in Binding and Uptake of Ligands by Scavenger ReceptorsPathwayReactome R-HSA-2173782Inferred only
APOL1 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
APOL1 participates in Nephrotic syndromePathwayWikiPathways WP4758Inferred only
APOL1 participates in Network map of SARS CoV 2 signalingPathwayWikiPathways WP5115Inferred only
APOL1 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
APOL1 participates in Post-translational protein phosphorylationPathwayReactome R-HSA-8957275Inferred only
APOL1 participates in Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)PathwayReactome R-HSA-381426Inferred only
APOL1 participates in Scavenging of heme from plasmaPathwayReactome R-HSA-2168880Inferred only
APOL1 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
AKR7A2 increases the expression of APOL1ProteinHetionet hetionet:regulates:8574-8542Inferred only
FOXO3 increases the expression of APOL1ProteinHetionet hetionet:regulates:2309-8542Inferred only

Show the remaining 6

GUK1 increases the expression of APOL1ProteinHetionet hetionet:regulates:2987-8542Inferred only
HRAS increases the expression of APOL1ProteinHetionet hetionet:regulates:3265-8542Inferred only
IFNG increases the expression of APOL1ProteinHetionet hetionet:regulates:3458-8542Inferred only
RARA increases the expression of APOL1ProteinHetionet hetionet:regulates:5914-8542Inferred only
TBC1D15 increases the expression of APOL1ProteinHetionet hetionet:regulates:64786-8542Inferred only
ZNF546 increases the expression of APOL1ProteinHetionet hetionet:regulates:339327-8542Inferred only

Other names

5 names

Resolves to: APOL1

Also called: Apo-LAPOLApoL-IApolipoprotein LApolipoprotein L-I

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