Proteins/UNIPROT:Q86SX6

GLRX5

ProteinUNIPROT:Q86SX6

Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer. Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1..

Function from UniProtKB (Q86SX6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

sideroblastic anemia 3 has a germline basis in GLRX5DiseaseGenCC HGNC:20134|MONDO:0014804Inferred only
spasticity-ataxia-gait anomalies syndrome has a germline basis in GLRX5DiseaseGenCC HGNC:20134|MONDO:0014803Inferred only

Statements

19 statements

19 statements · 4 reference databases · Subject: GLRX5 · Sources: Hetionet, Human-GEM, Reactome, WikiPathways

Order

APP interacts with GLRX5ProteinHetionet hetionet:interacts:351-51218Inferred only
KEAP1 interacts with GLRX5ProteinHetionet hetionet:interacts:51218-9817Inferred only
VHL interacts with GLRX5ProteinHetionet hetionet:interacts:51218-7428Inferred only
GLRX5 participates in Glycine metabolism including IMDsPathwayWikiPathways WP5028Inferred only
GLRX5 participates in Iron sulfur cluster biogenesisPathwayWikiPathways WP5152Inferred only
GLRX5 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
GLRX5 participates in Mitochondrial iron-sulfur cluster biogenesisPathwayReactome R-HSA-1362409Inferred only
AKR7A2 decreases the expression of GLRX5ProteinHetionet hetionet:regulates:8574-51218Inferred only
AKT1 decreases the expression of GLRX5ProteinHetionet hetionet:regulates:207-51218Inferred only
ALAS1 increases the expression of GLRX5ProteinHetionet hetionet:regulates:211-51218Inferred only
ECD increases the expression of GLRX5ProteinHetionet hetionet:regulates:11319-51218Inferred only
LOXL1 increases the expression of GLRX5ProteinHetionet hetionet:regulates:4016-51218Inferred only

Show the remaining 7

PAN2 decreases the expression of GLRX5ProteinHetionet hetionet:regulates:9924-51218Inferred only
SHH decreases the expression of GLRX5ProteinHetionet hetionet:regulates:6469-51218Inferred only
STAT3 increases the expression of GLRX5ProteinHetionet hetionet:regulates:6774-51218Inferred only
TSHZ3 decreases the expression of GLRX5ProteinHetionet hetionet:regulates:57616-51218Inferred only
UBE2E3 increases the expression of GLRX5ProteinHetionet hetionet:regulates:10477-51218Inferred only
VDAC1 decreases the expression of GLRX5ProteinHetionet hetionet:regulates:7416-51218Inferred only
di-mu-sulfido-diiron(2+) is a substrate of GLRX5CompoundHuman-GEM MAR20184Inferred only

Reactions

1 reaction

2ATP+2water+NADPH(4-)+2di-mu-sulfido-diiron(2+)2ADP+3proton+NADP(3-)+2phosphate(3-)+tetra-mu3-sulfido-tetrairon(2+)
Catalysed by FDXR & HSPA9 & IBA57 & FDX2 & GLRX5 & ISCA2 & HSCB & ISCA1

Other names

3 names

Resolves to: GLRX5

Also called: C14orf87Glutaredoxin-related protein 5, mitochondrialMonothiol glutaredoxin-5

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