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Proteins/UNIPROT:Q9Y287
Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.
Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.
Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.
Function from UniProtKB (Q9Y287), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
12 statements
12 statements · 3 reference databases · Subject: ITM2B · Sources: gene ontology, Hetionet, Reactome
15 names
Resolves to: ITM2B