a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine

Three steps

• glycerolReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA
  3. a 1-acylglycerol + a 1,2-diacylglycerol = a triacylglycerol + glycerol

  Catalysed by LPCAT4, MOGAT2, MOGAT3, LPGAT1 and 5 moreOne of 3 routes

• CHEBI:17927Reach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by LPCAT4, GPAT3, GPAT2, GPAT4 and 1 moremitochondrial matrix, cytosol

• a diacylglycerolReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)

  Catalysed by LPCAT4, DGAT1, MOGAT2, MOGAT3 and 21 morecytosolOne of 2 routes

• L-glutamineReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by LPCAT4, GLYATL1B, GLYATL1

• CHEBI:18132Reach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine
  3. sn-Glycero-3-phosphocholine cholinephosphohydrolase

  Catalysed by LPCAT4, PLA2G4C, ENPP6cytosol

• dodecanoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Lauroyl-CoA hydrolase

  Catalysed by LPCAT4, ACOT7, BAAT, ACOT1 and 1 morecytosolOne of 2 routes

• phosphatidyl-L-serineReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. phosphatidylserine synthase (PC-LD pool)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 1 morecytosolOne of 2 routes

• (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoAReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoA + H2O2

  Catalysed by LPCAT4, ACOX1cytosol

• 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by LPCAT4, LPGAT1cytosol

• 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. eicosanoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by LPCAT4, MOGAT2, MOGAT1cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by LPCAT4, GPAT3, GPAT2, GPAT4 and 4 moremitochondrial matrixOne of 2 routes

• 3-oxo-(9Z)-eicosenoyl-CoAReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. very-long-chain 3-oxoacyl-CoA synthase ((7Z)-octadecenoyl-CoA)

  Catalysed by LPCAT4, ELOVL7, ELOVL1, ELOVL4 and 4 morecytosol

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by LPCAT4, GPAT3, GPAT2, GPAT4 and 4 moremitochondrial matrixOne of 5 routes

• (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoAReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. (6Z,9Z,12Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by LPCAT4, ACADL, ACADVL, ACAD9cytosolOne of 2 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by LPCAT4, GPAT3, GPAT2, GPAT4 and 4 moremitochondrial matrixOne of 2 routes

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by LPCAT4, GPAT3, GPAT2, GPAT4 and 4 moremitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by LPCAT4, GPAT3, GPAT2, GPAT4 and 4 moremitochondrial matrixOne of 2 routes

• docosanoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Docosanoyl-CoA hydrolase

  Catalysed by LPCAT4, BAAT, ACOT6cytosolOne of 4 routes

• octadecanoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Stearoyl-CoA hydrolase

  Catalysed by LPCAT4, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 4 routes

• alpha-linolenic acidReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Linolenoyl-CoA hydrolase

  Catalysed by LPCAT4, ACOT7, BAAT, ACOT1cytosol

• CHEBI:27540Reach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by LPCAT4, GPAT3, GPAT2, GPAT4 and 7 moremitochondrial matrix, cytosolOne of 6 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase

  Catalysed by LPCAT4, BAAT, ACOT6cytosolOne of 2 routes

• hexacosan-1-olReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. hexacosanoyl-CoA + 2 NADPH + 2 H(+) = hexacosan-1-ol + 2 NADP(+) + CoA

  Catalysed by LPCAT4, FAR2cytosol

• 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by LPCAT4, PLA2G4C, TAFAZZIN

• CHEBI:28701Reach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by LPCAT4, GPAT3, GPAT2, GPAT4 and 4 moremitochondrial matrix, peroxisomeOne of 7 routes

• a fatty acidReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)

  Catalysed by LPCAT4, DGAT1, MOGAT2, MOGAT3 and 21 morecytosolOne of 26 routes

• phosphocholineReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = phosphocholine + a 1,2-diacyl-sn-glycerol + H(+)

  Catalysed by LPCAT4, LPGAT1, SMPD1One of 4 routes

• (9Z,12Z)-octadecadienoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. (9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)

  Catalysed by LPCAT4, ACOT8, ACOT2, THEM5 and 1 morecytosol

• tetradecanoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Myristoyl-CoA hydrolase

  Catalysed by LPCAT4, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Oleoyl-CoA hydrolase

  Catalysed by LPCAT4, ACOT7, BAAT, THEM4 and 2 morecytosol

• a 1-O-alkyl-sn-glycero-3-phosphocholineReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 6 morecytosolOne of 4 routes

• docosan-1-olReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. docosanoyl-CoA + 2 NADPH + 2 H(+) = docosan-1-ol + 2 NADP(+) + CoA

  Catalysed by LPCAT4, FAR2cytosol

• hexacosanoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Hexacosanoyl-CoA hydrolase

  Catalysed by LPCAT4, BAAT, ACOT6cytosolOne of 2 routes

• tetracosanoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Tetracosenoyl-CoA hydrolase

  Catalysed by LPCAT4, BAAT, THEM4cytosolOne of 4 routes

• an N-acyl-(4R)-4-hydroxysphinganineReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. sphingosine N-acyltransferase (sphinganine)
  3. dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)

  Catalysed by LPCAT4, CERS1, CERS6, CERS3 and 5 morecytosolOne of 3 routes

• octadecan-1-olReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. octadecanoyl-CoA + 2 NADPH + 2 H(+) = octadecan-1-ol + 2 NADP(+) + CoA

  Catalysed by LPCAT4, FAR1, FAR2cytosol

• eicosanoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Eicosanoyl-CoA hydrolase

  Catalysed by LPCAT4, BAAT, ACOT6, ACOT1cytosolOne of 4 routes

• (9Z)-hexadecenoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Palmitoleoyl-CoA hydrolase

  Catalysed by LPCAT4, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 2 routes

• (15Z)-tetracosenoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. (15Z)-tetracosenoyl-CoA hydrolase

  Catalysed by LPCAT4, BAAT, ACOT6cytosol

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Arachidonyl-CoA hydrolase

  Catalysed by LPCAT4, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 2 routes

• (11Z)-eicosenoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. (11Z)-eicosenoyl-CoA hydrolase

  Catalysed by LPCAT4, BAAT, ACOT6, ACOT1cytosol

• 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholineReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine
  3. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPCAT4, PAFAH2

• 1-O-hexadecyl-sn-glycerolReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine
  3. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycerol + phosphocholine + H(+)

  Catalysed by LPCAT4, PAFAH2, SMPD2

• fatty acidReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. triacylglycerol acylhydrolase

  Catalysed by LPCAT4, DGAT1, MOGAT2, MOGAT3 and 3 morecytosol, extracellular spaceOne of 24 routes

• a 1-acylglycerolReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA
  3. a 1,2-diacylglycerol + H2O = a 1-acylglycerol + a fatty acid + H(+)

  Catalysed by LPCAT4, MOGAT2, MOGAT3, LPGAT1 and 3 moreOne of 2 routes

• a sterol esterReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  3. a sterol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sterol ester + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by LPCAT4, LPGAT1, LCAT

• cholesteryl hexadecanoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by LPCAT4, SOAT2, SOAT1cytosol, endoplasmic reticulumOne of 5 routes

• cholesteryl (9Z,12Z)-octadecadienoateReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by LPCAT4, SOAT2, SOAT1cytosol, endoplasmic reticulumOne of 6 routes

• 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholineReach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine
  3. 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPCAT4, PAFAH2, LPCAT2, LPCAT1

• cholesteryl (9Z-octadecenoate)Reach from here →
  1. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by LPCAT4, SOAT2, SOAT1cytosol, endoplasmic reticulumOne of 5 routes