O-dodecanoyl-R-carnitine

Three steps

• L-leucineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Carnitine Transport by Atb0
  3. transport of chloride and leucine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14cytosol, extracellular spaceOne of 2 routes

• 12(S)-HPETEReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. arachidonate:oxygen 12-oxidoreductase

  Catalysed by CPT1A, CPT1C, CPT1B, ALOX12cytosol, endoplasmic reticulumOne of 4 routes

• 15(S)-HPETEReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. arachidonate:oxygen 15-oxidoreductase

  Catalysed by CPT1A, CPT1C, CPT1B, ALOX15B and 1 morecytosol, endoplasmic reticulumOne of 4 routes

• 5(S)-HPETEReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. Arachidonate:oxygen 5-oxidoreductase

  Catalysed by CPT1A, CPT1C, CPT1B, ALOX5cytosol, endoplasmic reticulum

• CHEBI:15650Reach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 35 morecytosolOne of 2 routes

• CHEBI:15727Reach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 4 morecytosol

• CHEBI:15746Reach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 5 morecytosolOne of 2 routes

• 1-acylglycerone 3-phosphateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:glycerone-phosphate O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, GNPATcytosol

• CHEBI:15971Reach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Carnitine Transport by Atb0
  3. transport of chloride and histidine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14cytosol, extracellular space

• phosphatidylethanolamineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, LPCAT4 and 4 morecytosol

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, LPCAT4 and 3 morecytosol

• sulfateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Carnitine Transport by Atb0
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14 and 1 morecytosol, extracellular space

• 11-cis-retinolReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 8 morecytosol

• phosphatidic acidReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. acyl-CoA pool formation and breakdown
  3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, AGPAT2 and 8 morecytosol, mitochondrial matrixOne of 7 routes

• iodideReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Carnitine Transport by Atb0
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14 and 1 morecytosol, extracellular space

• L-valineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Carnitine Transport by Atb0
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14cytosol, extracellular spaceOne of 2 routes

• oxaloacetateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. ATP citrate lyase (citrate)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 4 morecytosol

• L-arginineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Carnitine Transport by Atb0
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14cytosol, extracellular spaceOne of 2 routes

• 8-hydroxydodecanoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 8-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 4 morecytosol

• 10-hydroxydodecanoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 4 morecytosol

• 9-hydroxydodecanoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 9-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 4 morecytosol

• CHEBI:16856Reach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

• CHEBI:16857Reach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Carnitine Transport by Atb0
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14cytosol, extracellular space

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation

  Catalysed by CPT1A, CPT1C, CPT1B, GPAT3 and 3 morecytosolOne of 9 routes

• oxalic acidReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Carnitine Transport by Atb0
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14 and 1 morecytosol, extracellular space

• a cholesterol esterReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + cholesterol = a cholesterol ester + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SOAT2 and 1 morecytosol

• L-isoleucineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Carnitine Transport by Atb0
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14cytosol, extracellular spaceOne of 2 routes

• CHEBI:17203Reach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Carnitine Transport by Atb0
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14 and 2 morecytosol, extracellular spaceOne of 2 routes

• itaconateReach from here →
  1. dodecanoyl-CoA + (R)-carnitine = O-dodecanoyl-R-carnitine + CoA
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate

  Catalysed by CPT2, SLC22A8, SUGCTinner side of the membrane, outer side of the membrane

• anilineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 5 morecytosol

• CHEBI:17312Reach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 3 morecytosolOne of 2 routes

• 3-hydroxy-3-methylglutarateReach from here →
  1. dodecanoyl-CoA + (R)-carnitine = O-dodecanoyl-R-carnitine + CoA
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate

  Catalysed by CPT2, SLC22A8, SUGCTinner side of the membrane, outer side of the membrane

• 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, LPCAT4 and 3 morecytosol

• L-cysteineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 4 morecytosol, mitochondrial matrixOne of 3 routes

• hexadecanalReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. 2 H+[c] + NADH[c] + palmitate[c] = H2O[c] + hexadecanal[c] + NAD+[c]

  Catalysed by CPT1A, CPT1C, CPT1B, ALDH3B1 and 2 morecytosol, endoplasmic reticulumOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 6 morecytosol, mitochondrial matrix

• CHEBI:17724Reach from here →
  1. dodecanoyl-CoA + (R)-carnitine = O-dodecanoyl-R-carnitine + CoA
  2. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)
  3. Trimethylaminoacetate:L-homosysteine S-methyltransferase

  Catalysed by CPT2, SLC22A5, BHMT, BHMT2inner side of the membrane, outer side of the membrane, cytosol

• urateReach from here →
  1. dodecanoyl-CoA + (R)-carnitine = O-dodecanoyl-R-carnitine + CoA
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. urate(in) + glutarate(out) = urate(out) + glutarate(in)

  Catalysed by CPT2, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• a 1,2-diacyl-sn-glycerolReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. acyl-CoA pool formation and breakdown
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, MOGAT2 and 2 morecytosol

• a triacylglycerolReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. acyl-CoA pool formation and breakdown
  3. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, DGAT1 and 4 morecytosol

• CHEBI:17895Reach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Carnitine Transport by Atb0
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14cytosol, extracellular spaceOne of 2 routes

• CHEBI:17927Reach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 3 morecytosol

• butanoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  3. butanoyl-CoA + H2O = butanoate + CoA + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC33A1 and 8 morecytosol, mitochondrial matrix

• CHEBI:18019Reach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Carnitine Transport by Atb0
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14cytosol, extracellular space

• L-glutamineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Carnitine Transport by Atb0
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14cytosol, extracellular space

• CHEBI:18095Reach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Carnitine Transport by Atb0
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14 and 2 morecytosol, extracellular space

• N-carbamoyl-beta-alanineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Carnitine Transport by Atb0
  3. Transport of 3-Ureidopropionate

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14cytosol, extracellular spaceOne of 2 routes

• 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)Reach from here →
  1. dodecanoyl-CoA + (R)-carnitine = O-dodecanoyl-R-carnitine + CoA
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by CPT2, SLC22A8, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• 1-butanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  3. 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SLC33A1 and 4 morecytosol, mitochondrial matrix

• (5Z)-dodecenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 6 morecytosol, mitochondrial matrixOne of 4 routes