3-oxooctadecanoyl-CoA

Three steps

• isobutyryl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosol, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 4 moreperoxisome, cytosol, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 12 routes

• CHEBI:15519Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 4 moreperoxisome, cytosolOne of 2 routes

• oleoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosolOne of 15 routes

• phenylacetyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Phenylacetate:CoA ligase

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosolOne of 43 routes

• CHEBI:15650Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 35 moreperoxisome, cytosolOne of 2 routes

• CHEBI:15727Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 4 moreperoxisome, cytosol

• CHEBI:15746Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 5 moreperoxisome, cytosolOne of 2 routes

• 1-acylglycerone 3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:glycerone-phosphate O-acyltransferase

  Catalysed by ACAA1, MYO5B, GNPATperoxisome, cytosol

• phosphatidylethanolamineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

  Catalysed by ACAA1, MYO5B, LPCAT4, LPCAT3 and 3 moreperoxisome, cytosol

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by ACAA1, MYO5B, LPCAT4, LPCAT3 and 2 moreperoxisome, cytosol

• cholesterolReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
  3. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine

  Catalysed by SCP2, HADHB, CERS6, TLCD3B and 3 more

• 11-cis-retinolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 8 moreperoxisome, cytosolOne of 3 routes

• phosphatidic acidReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by ACAA1, MYO5B, AGPAT2, LCLAT1 and 7 moreperoxisome, cytosol, mitochondrial matrixOne of 7 routes

• (R)-carnitineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  3. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA

  Catalysed by ACAA1, MYO5B, CPT2, CPT1A and 1 moreperoxisomeOne of 3 routes

• oxaloacetateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. ATP citrate lyase (citrate)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 4 moreperoxisome, cytosol

• CHEBI:16566Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)
  3. Sphinganine:NADP+ 3-oxidoreductase

  Catalysed by ACAA1, MYO5B, SPTLC1, SPTLC2 and 2 moreperoxisome, cytosol

• 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
  3. 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoate + H(+)

  Catalysed by SCP2, HADHB, LCLAT1, DDHD1

• sn-glycerol 3-phosphocholineReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = sn-glycerol 3-phosphocholine + 2 hexadecanoate + 2 H(+)

  Catalysed by SCP2, HADHB, PRDX6, LPCAT3 and 2 more

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)
  3. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation

  Catalysed by ACAA1, MYO5B, GPAT3, GPAT2 and 2 moreperoxisome, cytosolOne of 9 routes

• a cholesterol esterReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Acyl-CoA:cholesterol O-acyltransferase
  3. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion

  Catalysed by ACAA1, MYO5B, SOAT2, SOAT1peroxisome, endoplasmic reticulumOne of 4 routes

• S-(9Z-hexadecenoyl)-4'-phosphopantetheineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
  3. (9Z)-hexadecenoyl-CoA + H2O = S-(9Z-hexadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by ACAA1, MYO5B, SCD, NUDT19peroxisome, cytosol

• N-octadecanoyl-heptadecasphing-4-enineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. heptadecasphing-4-enine + octadecanoyl-CoA = N-octadecanoyl-heptadecasphing-4-enine + CoA + H(+)

  Catalysed by ACAA1, MYO5B, CERS1peroxisome, cytosol

• anilineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 5 moreperoxisome, cytosol

• CHEBI:17312Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosolOne of 2 routes

• all-trans-retinolReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA
  3. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)

  Catalysed by SCP2, HADHB, DGAT1, PNPLA4 and 5 more

• 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase

  Catalysed by ACAA1, MYO5B, LPCAT4, LPCAT3 and 2 moreperoxisome, cytosol

• L-cysteineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 4 moreperoxisome, cytosol, mitochondrial matrix

• hexadecanalReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. 2 H+[c] + NADH[c] + palmitate[c] = H2O[c] + hexadecanal[c] + NAD+[c]

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosolOne of 3 routes

• a sphingomyelinReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin

  Catalysed by SCP2, HADHB, PRDX6, LPCAT3 and 2 more

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosol, mitochondrial matrix

• a 1,2-diacyl-sn-glycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA

  Catalysed by ACAA1, MYO5B, MOGAT2, AWAT2 and 1 moreperoxisome, cytosolOne of 5 routes

• a triacylglycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

  Catalysed by ACAA1, MYO5B, DGAT1, MOGAT2 and 3 moreperoxisome, cytosol

• CHEBI:17927Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosol

• O-octanoyl-(R)-carnitineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrixOne of 4 routes

• superoxideReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-peroxy-docosahexaenoate to DHA conversion

  Catalysed by ACAA1, MYO5B, DGAT1, LRAT and 3 moreperoxisome, cytosol

• 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACAA1, MYO5B, LPGAT1peroxisome, cytosol

• 1-octanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 2 moreperoxisome, mitochondrial matrix

• (5Z)-dodecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 6 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
  3. Fatty Acid Beta Oxidation (C16:1->C14:1), Mitochondrial

  Catalysed by ACAA1, MYO5B, SCD, HADHA and 2 moreperoxisome, cytosol, mitochondrial matrixOne of 11 routes

• S-hexadecanoyl-N-acetylcysteamineReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)
  3. S-hexadecanoyl-N-acetylcysteamine + H2O = N-acetylcysteamine + hexadecanoate + H(+)

  Catalysed by SCP2, HADHB, ACOT7, ACOT8 and 15 more

• S-hexadecanoyl-N-acetylcysteine methyl esterReach from here →
  1. hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
  2. hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)
  3. S-hexadecanoyl-N-acetylcysteine methyl ester + H2O = N-acetylcysteine methyl ester + hexadecanoate + H(+)

  Catalysed by SCP2, HADHB, ACOT7, ACOT8 and 15 more

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxooctadecanoyl-CoA)
  2. Palmitoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosol, mitochondrial matrixOne of 2 routes