3-oxotetradecanoyl-CoA

Three steps

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 8 routes

• butanoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 8 moreperoxisome, cytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. Production of Glutaryl Carnitine

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 5 moreperoxisome, cytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 13 routes

• itaconyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 5 moreperoxisome, cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 14 routes

• octanoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosol, mitochondrial matrixOne of 21 routes

• phytanoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. phytanate-CoA ligase

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 2 moreperoxisome, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 9 moreperoxisome, cytosolOne of 16 routes

• a 1-acylglycerone 3-phosphateReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. acyl-CoA pool formation and breakdown
  3. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, GNPATperoxisome, cytosol

• a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. acyl-CoA pool formation and breakdown
  3. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, MYO5B, LPGAT1peroxisome, cytosolOne of 2 routes

• an N-acylglycineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by ACAA1, MYO5B, GLYATL3, GLYAT and 1 moreperoxisome, cytosol

• sphing-4-enineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 4 moreperoxisome, cytosolOne of 3 routes

• L-methionineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosol, mitochondrial matrix

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by ACAA1, MYO5B, LCLAT1, MBOAT7peroxisome, cytosol

• a 1-acyl-sn-glycero-3-phosphateReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. acyl-CoA pool formation and breakdown
  3. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, GPAT3, GPAT2 and 2 moreperoxisome, cytosol

• L-alanineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 2 moreperoxisome, cytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosol, mitochondrial matrix

• (3Z)-dodecenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 5 moreperoxisome, cytosol, mitochondrial matrixOne of 5 routes

• a 1,2-diacyl-sn-glycero-3-phosphateReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, AGPAT2, GPAT3 and 11 moreperoxisome, cytosol

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 4 moreperoxisome, cytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 4 moreperoxisome, cytosolOne of 4 routes

• monodehydro-L-ascorbate radicalReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by ACAA1, MYO5B, GLYATL2, PAMperoxisome

• (2E)-tetradecenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. trans-tetradec-2-enoyl-CoA reductase

  Catalysed by ACAA1, MYO5B, MECRperoxisome, cytosol, mitochondrial matrixOne of 5 routes

• (2E)-decenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Fatty Acid Beta Oxidation (C12->C10), Mitochondrial
  3. trans-dec-2-enoyl-CoA reductase

  Catalysed by ACAA1, MYO5B, ACADM, ECHS1 and 3 moreperoxisome, mitochondrial matrixOne of 5 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 5 moreperoxisome, cytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 12 routes

• a cardiolipinReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. acyl-CoA pool formation and breakdown
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA

  Catalysed by ACAA1, MYO5B, HADHAperoxisome, cytosol

• 3-hydroxyisovaleryl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 4 moreperoxisome, cytosol

• an all-trans-retinyl esterReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. acyl-CoA pool formation and breakdown
  3. all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA

  Catalysed by ACAA1, MYO5B, DGAT1, PNPLA4 and 2 moreperoxisome, cytosol

• CHEBI:63544Reach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 8 routes

• a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACAA1, MYO5B, LPCAT4, LPCAT3 and 2 moreperoxisome, cytosol

• a triacyl-sn-glycerolReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

  Catalysed by ACAA1, MYO5B, DGAT1, MOGAT2 and 4 moreperoxisome, cytosol

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. acyl-CoA pool formation and breakdown
  3. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by ACAA1, MYO5B, LCLAT1, LPCAT1 and 1 moreperoxisome, cytosol

• hexacosanoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 6 routes

• tetracosanoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 11 routes

• docosanoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 10 routes

• N-(tetradecanoyl)-sphinganineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. sphinganine + tetradecanoyl-CoA = N-(tetradecanoyl)-sphinganine + CoA + H(+)

  Catalysed by ACAA1, MYO5B, CERS6, CERS5peroxisome, cytosol

• 3-oxohexadecasphinganineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. tetradecanoyl-CoA + L-serine + H(+) = 3-oxohexadecasphinganine + CO2 + CoA

  Catalysed by ACAA1, MYO5B, SPTLC1, SPTLC3peroxisome, cytosol

• (2E)-octadecenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 5 moreperoxisome, cytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 9 routes

• 1-tetradecanoyl-sn-glycerol 3-phosphateReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. glycerol-3-phosphate 1-O-acyltransferase (myristoyl-CoA)

  Catalysed by ACAA1, MYO5B, GPAT3, GPAT2 and 2 moreperoxisome, cytosol

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, AGPAT2peroxisome, cytosol

• N-dodecanoylsphing-4-enineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosol

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 10 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 7 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 8 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 7 routes