N(8)-acetylspermidine

Three steps

• L-alanineReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by SAT1, SAT2cytosol, mitochondrial matrixOne of 19 routes

• L-asparagineReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by SAT1, SAT2, NAGScytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by SAT1, SAT2, NAGScytosol, mitochondrial matrix

• a 1-acyl-sn-glycero-3-phosphocholineReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by HDAC10, ASAH1, PLA2G15

• 4-aminobutanalReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  3. putrescine + O2 + H2O = 4-aminobutanal + H2O2 + NH4(+)

  Catalysed by SRM, AOC1cytosol

• an acyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by SAT1, SAT2, ASAH1, ACER2 and 2 morecytosol, Golgi apparatusOne of 2 routes

• 3-aminopropanalReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. S-adenosylmethioninamine:spermidine 3-aminopropyltransferase
  3. spermidine:oxygen oxidoreductase (spermidine-forming)

  Catalysed by SRM, SMS, SMOXcytosolOne of 3 routes

• cadaverineReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. N-acetylcadaverine + H2O = cadaverine + acetate
  3. N-acetylcadaverine + H2O = cadaverine + acetate

  Catalysed by HDAC10

• 5-(methylsulfanyl)-alpha-D-ribose 1-phosphateReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. S-adenosylmethioninamine:spermidine 3-aminopropyltransferase
  3. S-methyl-5'-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase

  Catalysed by SRM, SMS, MTAPcytosolOne of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by SAT1, SAT2, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• N(1),N(12)-diacetylspermineReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. spermidine + acetyl-CoA = N(1)-acetylspermidine + CoA + H(+)
  3. N(1),N(12)-diacetylspermine + O2 + H2O = 3-acetamidopropanal + N(1)-acetylspermidine + H2O2

  Catalysed by SAT1, PAOXcytosol

• (3S)-citramalyl-CoAReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by SAT1, SAT2, SLC27A2, SLC27A5cytosol, endoplasmic reticulumOne of 3 routes

• an S-substituted L-cysteineReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate
  3. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

  Catalysed by HDAC10, ACY3

• D-glucosamine 6-phosphateReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate
  3. D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)

  Catalysed by HDAC10, AMDHD2, GNPNAT1One of 2 routes

• 5-amino-2-oxopentanoateReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

• deoxycholoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by SAT1, SAT2, SLC27A2, SLC27A5cytosolOne of 4 routes

• 4-aminobutanoateReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. spermidine:(acceptor) oxidoreductase
  3. 4-Aminobutyraldehyde:NAD+ oxidoreductase

  Catalysed by ALDH2, ALDH1B1, ALDH9A1, ALDH7A1 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• decanoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by SAT1, SAT2, ACSM4, ACSM1 and 4 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by SAT1, SAT2, CPT1A, CPT1C and 1 morecytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 11 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

• 3-hydroxyisovaleryl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by SAT1, SAT2, CPT1A, CPT1Bcytosol

• CHEBI:63544Reach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• a 1-acyl-sn-glycero-3-phospho-L-serineReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. a 1,2-diacyl-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phospho-L-serine

  Catalysed by HDAC10, ASAH1, PLA2G15

• a 1-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine

  Catalysed by HDAC10, ASAH1, PLA2G15

• 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)

  Catalysed by HDAC10, ASAH1, PLA2G15

• hexacosanoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 9 routes

• a 2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine

  Catalysed by HDAC10, ASAH1, PLA2G15

• a 2-acyl-sn-glycero-3-phospho-L-serineReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. a 1,2-diacyl-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = a 2-acyl-sn-glycero-3-phospho-L-serine + 1-O-acyl-N-(acetyl)-sphing-4-enine

  Catalysed by HDAC10, ASAH1, PLA2G15

• 2-acetamido-2-deoxy-D-glucopyranose 1-phosphateReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate
  3. phosphoglucomutase (N-acetylglucosamine-6-phosphate)

  Catalysed by HDAC10, AMDHD2, PGM3cytosol

• (2E)-octadecenoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by SAT1, SAT2, CPT1A, CPT1C and 1 morecytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

• 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine

  Catalysed by HDAC10, ASAH1, PLA2G15

• 1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by HDAC10, ASAH1, PLA2G15One of 4 routes

• 1-hexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine

  Catalysed by HDAC10, ASAH1, PLA2G15One of 3 routes

• 1-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by HDAC10, ASAH1, PLA2G15One of 3 routes

• 4-acetamidobutanalReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. N-acetylputrescine + H2O = putrescine + acetate
  3. N-Acetylputrescine:oxygen oxidoreductase(deaminating)(flavin-containing)

  Catalysed by HDAC10, AOC2, AOC1, MAOA and 2 morecytosolOne of 2 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 4 routes