Compound

a 1-acyl-sn-glycero-3-phospho-L-serine

A singly-charged anionic phospholipid that is the conjugate base of 1-acyl-sn-glycero-3-phosphoserine, in which the carboxy and phosphate groups are anionic and the amino group is cationic; major species at pH 7.3.

Definition from ChEBI (CHEBI:64379), read 2026-09-23. CC BY 4.0.

CHEBI:64379ChEBI

Open in the graph

Structure

2D depiction

Class: Organic compound, anion
Formula: C7H12NO9PR
Mass: 285.146 g/mol
Charge: -1
SMILES: *C(=O)OC[C@@H](O)COP(=O)([O-])OC[C@H]([NH3+])C(=O)[O-]
Look it up: ChEBI

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

6 entities

6 entities reached.

0 reported hops6 assembled from the scaffold

What the reference databases state

Statements

9 statements

9 statements · 1 reference database · Subject: a 1-acyl-sn-glycero-3-phospho-L-serine · Sources: Rhea

Order

a 1-acyl-sn-glycero-3-phospho-L-serine is converted to a 1-acyl-sn-glycero-3-phosphateCompoundRhea RHEA:38999Inferred only
a 1-acyl-sn-glycero-3-phospho-L-serine is a substrate of ABHD12ProteinRhea RHEA:32979Inferred only
a 1-acyl-sn-glycero-3-phospho-L-serine is a substrate of ENPP2ProteinRhea RHEA:38999Inferred only
a 1-acyl-sn-glycero-3-phospho-L-serine is a substrate of LPCAT3ProteinRhea RHEA:33191Inferred only
a 1-acyl-sn-glycero-3-phospho-L-serine is a substrate of LPCAT3ProteinRhea RHEA:37567Inferred only
a 1-acyl-sn-glycero-3-phospho-L-serine is a substrate of LPCAT3ProteinRhea RHEA:37571Inferred only
a 1-acyl-sn-glycero-3-phospho-L-serine is a substrate of LPCAT4ProteinRhea RHEA:33191Inferred only
a 1-acyl-sn-glycero-3-phospho-L-serine is a substrate of MBOAT1ProteinRhea RHEA:33191Inferred only
a 1-acyl-sn-glycero-3-phospho-L-serine is a substrate of PLA1AProteinRhea RHEA:32979Inferred only

Reactions

9 reactions

a 1-acyl-sn-glycero-3-phospho-L-serine+watersn-glycero-3-phospho-L-serine+a fatty acid+hydron
Catalysed by PLA1A or ABHD12
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:32979CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phospho-L-serine+an acyl-CoAa 1,2-diacyl-sn-glycero-3-phospho-L-serine+coenzyme A(4-)
Catalysed by LPCAT4 or LPCAT3 or MBOAT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:33191CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phospho-L-serine+(9Z,12Z)-octadecadienoyl-CoA1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine+coenzyme A(4-)
Catalysed by LPCAT3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:37567CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phospho-L-serine+(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine+coenzyme A(4-)
Catalysed by LPCAT3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:37571CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phospho-L-serine+(9Z)-octadecenoyl-CoACHEBI:75242+coenzyme A(4-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:37735CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phospho-L-serine+(9Z)-hexadecenoyl-CoACHEBI:75241+coenzyme A(4-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:37739CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phospho-L-serine+watera 1-acyl-sn-glycero-3-phosphate+L-seryl residue+hydron
Catalysed by ENPP2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:38999CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-L-serine+watera 1-acyl-sn-glycero-3-phospho-L-serine+a fatty acid+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:44672CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-L-serine+N-(acetyl)-sphing-4-enine1-O-acyl-N-(acetyl)-sphing-4-enine+a 1-acyl-sn-glycero-3-phospho-L-serine
Catalysed by PLA2G15
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:78351CC BY 4.0Reference data

Other names

3 names

Resolves to: a 1-acyl-sn-glycero-3-phospho-L-serine

Also called: 1-acyl-sn-glycero-3-phospho-L-serine1-acyl-sn-glycero-3-phosphoserine anionLPS