L-kynurenine

1. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

Catalysed by KYAT3, AADAT, GLYATL2One of 2 routes

1. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
2. (R)-4'-phosphopantothenate:L-cysteine ligase

Catalysed by AADAT, PPCScytosolOne of 4 routes

1. an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)
2. an N-acyl-L-amino acid + H2O = an L-alpha-amino acid + a carboxylate

Catalysed by SLC7A11, ACY1, PM20D1inner side of the membrane, outer side of the membrane

1. L-Kynurenine hydrolase
2. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

Catalysed by KYNU, SLC1A4cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
2. Hippurate (Benzoylglycinate) Formation

Catalysed by KYAT3, AADATmitochondrial matrixOne of 2 routes

1. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
2. L-Cysteine:oxygen oxidoreductase

Catalysed by AADAT, CDO1cytosolOne of 2 routes

1. L-Kynurenine hydrolase
2. gamma-glutamyltransferase (alanine)

Catalysed by KYNU, GGTLC3, GGT1, GGT5 and 3 morecytosolOne of 2 routes

1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
2. Kynurenine-Oxoglutarate Transaminase

Catalysed by KMO, AADATcytosol, mitochondrial matrixOne of 3 routes

1. L-Kynurenine hydrolase
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by KYNU, MOCOScytosol

1. an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)
2. an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid

Catalysed by SLC7A11, DPEP1, DPEP2inner side of the membrane, outer side of the membrane

1. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by AADAT, MOCOS

1. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
2. Glycodeoxycholate amidohydrolase

Catalysed by KYAT3, AADATcytosolOne of 2 routes

1. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

Catalysed by KYAT3, AADAT, GLYATL2

1. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
2. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

Catalysed by KYAT3, AADAT, BAAT

1. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
2. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

Catalysed by KYAT3, AADAT, BAAT

1. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
2. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

Catalysed by KYAT3, AADAT, BAAT

1. L-Kynurenine hydrolase
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. Carnitine O-Palmitoyltransferase

Catalysed by KYNU, CPT1A, CPT1C, CPT1Bcytosol, mitochondrial matrixOne of 245 routes

1. L-Kynurenine hydrolase
2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
3. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)