(9Z)-octadecenoyl-CoA

Three steps

• 5-aminolevulinic acidReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 3 moremitochondrial matrix

• O-phosphoethanolamineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
  3. ATP:ethanolamine O-phosphotransferase

  Catalysed by MBOAT1, MBOAT2, PTDSS2, CHKA and 3 morecytosol

• L-cysteineReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SCD, SCD5, ACOT7, BAAT and 4 morecytosol, mitochondrial matrixOne of 5 routes

• hexadecanalReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoate + H(+)
  3. hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O

  Catalysed by AGPAT2, GPAT3, LCLAT1, MBOAT2 and 12 more

• all-trans-retinyl hexadecanoateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoate + H(+)
  3. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)

  Catalysed by AGPAT2, GPAT3, LCLAT1, MBOAT2 and 10 moreOne of 2 routes

• 26-hydroxycholesterolReach from here →
  1. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
  2. cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)
  3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 26-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SOAT2, SOAT1, CEL, CES1 and 4 more

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by SCD, SCD5, ACOT7, BAAT and 6 morecytosol, mitochondrial matrix

• desmosterolReach from here →
  1. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
  2. Steryl-ester acylhydrolase
  3. 3-hydroxyacyl-CoA dehydrogenase (desmosterol)

  Catalysed by SOAT2, SOAT1, CEL, LIPAlysosome, nucleus

• glycine betaineReach from here →
  1. (R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA
  2. (R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA
  3. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)

  Catalysed by CPT2, SLC22A5inner side of the membrane, outer side of the membraneOne of 2 routes

• a 1,2-diacyl-sn-glycerolReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. acyl-CoA pool formation and breakdown
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA

  Catalysed by SCD, SCD5, MOGAT2, AWAT2 and 1 morecytosol

• a triacylglycerolReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. acyl-CoA pool formation and breakdown
  3. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

  Catalysed by SCD, SCD5, DGAT1, MOGAT2 and 3 morecytosol

• CHEBI:17895Reach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 moreextracellular space, cytosolOne of 4 routes

• CHEBI:17927Reach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by SCD, SCD5, ACOT7, BAAT and 3 morecytosol

• 4-methylpentanalReach from here →
  1. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
  2. Steryl-ester acylhydrolase
  3. cytochrome P450 (cholesterol)

  Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 morelysosome, mitochondrial matrixOne of 2 routes

• CHEBI:18019Reach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 moreextracellular space, cytosolOne of 2 routes

• L-glutamineReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 moreextracellular space, cytosolOne of 4 routes

• O-octanoyl-(R)-carnitineReach from here →
  1. (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
  2. Utilized Transport
  3. solute carrier (L-carnitine)

  Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 5 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 10 routes

• dodecanoateReach from here →
  1. (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 4 morecytosol, extracellular spaceOne of 12 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 morecytosol

• cholesteryl 3-beta-D-galactosideReach from here →
  1. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
  2. cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)
  3. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + an N-acylsphing-4-enine

  Catalysed by SOAT2, SOAT1, CEL, CES1 and 5 moreOne of 2 routes

• cholesteryl 3-beta-D-xylosideReach from here →
  1. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
  2. cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)
  3. a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine

  Catalysed by SOAT2, SOAT1, CEL, CES1 and 5 moreOne of 2 routes

• beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enineReach from here →
  1. (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
  2. N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate
  3. N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose = beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + UDP + H(+)

  Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 10 more

• ophthalmateReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 more

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 more

• 1-butanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA
  2. 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)
  3. 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by DGAT1, MOGAT3, DGAT2, LIPC and 4 more

• 1-octanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA
  2. 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)
  3. 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by DGAT1, MOGAT3, DGAT2, LIPC and 4 more

• 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA
  2. 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)
  3. eicosanoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by DGAT1, MOGAT3, DGAT2, LIPC and 4 more

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 morecytosolOne of 2 routes

• O-butanoyl-(R)-carnitineReach from here →
  1. (R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA
  2. (R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA
  3. butanoyl-CoA + (R)-carnitine = O-butanoyl-(R)-carnitine + CoA

  Catalysed by CPT2, CRAT

• (5Z)-dodecenoyl-CoAReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by SCD, SCD5, ACOT7, BAAT and 6 morecytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by SCD, SCD5, ACOT7, BAAT and 11 morecytosolOne of 6 routes

• 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol)Reach from here →
  1. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
  2. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)
  3. 2 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + sn-glycero-3-phospho-(1'-sn-glycerol)

  Catalysed by LCLAT1, LPGAT1, PLA2G4A, CLN5

• 1-octadecanoyl-sn-glycero-3-phospho-(3'-octadecanoyl-1'-sn-glycerol)Reach from here →
  1. 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
  2. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine
  3. 2 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-sn-glycero-3-phospho-(3'-octadecanoyl-1'-sn-glycerol) + sn-glycero-3-phospho-(1'-sn-glycerol)

  Catalysed by LPCAT4, LCLAT1, PLA2G15, CLN5

• 1-hexadecanoyl-sn-glycero-3-phospho-(3'-hexadecanoyl-1'-sn-glycerol)Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)
  3. 2 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-sn-glycero-3-phospho-(3'-hexadecanoyl-1'-sn-glycerol) + sn-glycero-3-phospho-(1'-sn-glycerol)

  Catalysed by LCLAT1, LPGAT1, ABHD16A, PLA2G1B and 6 more

• (7Z)-tetradecenoyl-CoAReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by SCD, SCD5, ACOT7, BAAT and 11 morecytosolOne of 9 routes

• 3-oxo-(9Z)-eicosenoyl-CoAReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. stearoyl-CoA 9-desaturase (stearoyl-CoA)
  3. very-long-chain 3-oxoacyl-CoA synthase ((7Z)-octadecenoyl-CoA)

  Catalysed by SCD, SCD5, ELOVL7, ELOVL1 and 5 morecytosol

• a 2-hexadecanoyl-6-alpha-D-glucosaminy-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  3. a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + hexadecanoyl-CoA = a 2-hexadecanoyl-6-alpha-D-glucosaminy-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + CoA

  Catalysed by LPCAT3, MBOAT1, MBOAT2, LPCAT2 and 3 more

• S-hexadecanoyl-N-acetylcysteamineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoate + H(+)
  3. S-hexadecanoyl-N-acetylcysteamine + H2O = N-acetylcysteamine + hexadecanoate + H(+)

  Catalysed by AGPAT2, GPAT3, LCLAT1, MBOAT2 and 11 more

• S-hexadecanoyl-N-acetylcysteine methyl esterReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoate + H(+)
  3. S-hexadecanoyl-N-acetylcysteine methyl ester + H2O = N-acetylcysteine methyl ester + hexadecanoate + H(+)

  Catalysed by AGPAT2, GPAT3, LCLAT1, MBOAT2 and 10 more

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by SCD, SCD5, ACOT7, BAAT and 6 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by SCD, SCD5, ACOT7, BAAT and 6 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by SCD, SCD5, ACOT7, BAAT and 6 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by SCD, SCD5, ACOT7, BAAT and 6 morecytosol, mitochondrial matrixOne of 2 routes

• docosanoateReach from here →
  1. (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 4 morecytosol, extracellular spaceOne of 12 routes

• CHEBI:240943Reach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 2 moremitochondrial matrix

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
  3. fatty acylamide amidohydrolase

  Catalysed by MBOAT1, MBOAT2, PTDSS2, FAAHcytosolOne of 2 routes

• alpha-linolenic acidReach from here →
  1. (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 4 morecytosol, extracellular spaceOne of 13 routes

• phenylacetylglycineReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 morecytosolOne of 3 routes

• CHEBI:27540Reach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by SCD, SCD5, ACOT7, BAAT and 9 morecytosolOne of 6 routes

• L-glyceraldehydeReach from here →
  1. 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA
  2. 1-(9Z-octadecenoyl)-glycerol + 1,2-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol
  3. glycerol + NADP(+) = L-glyceraldehyde + NADPH + H(+)

  Catalysed by DGAT1, MOGAT2, AWAT2, DGAT2L6 and 7 more