Compound
O-phosphoethanolamine
The ethanolamine mono-ester of phosphoric acid, and a metabolite of phospholipid metabolism. This phosphomonoester shows strong structural similarity to the inhibitory neurotransmitter GABA, and is decreased in post-mortem Alzheimer's disease brain.
Definition from ChEBI (CHEBI:17553), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
5 entities
5 entities reached.
0 reported hops5 assembled from the scaffold
- CYP27A1ProteinUNIPROT:Q02318metabolized byInferred only29 paths29 endpoints
- PCYT2ProteinUNIPROT:Q99447substrate ofInferred only13 paths13 endpoints
- SGPL1ProteinUNIPROT:O95470substrate ofInferred only12 paths12 endpoints
- PHOSPHO1ProteinUNIPROT:Q8TCT1substrate ofInferred only6 paths6 endpoints
- ETNPPLProteinUNIPROT:Q8TBG4substrate ofInferred only5 paths5 endpoints
What the reference databases state
Statements
9 statements
9 statements · 1 reference database · Subject: O-phosphoethanolamine · Sources: Human-GEM
- O-phosphoethanolamine is converted to acetaldehydeCompoundHuman-GEM MAR04296Inferred only
- O-phosphoethanolamine is converted to CDP-ethanolamineCompoundHuman-GEM MAR00651Inferred only
- O-phosphoethanolamine is converted to ethanolamineCompoundHuman-GEM MAR00649Inferred only
- ethanolamine is converted to O-phosphoethanolamineCompoundHuman-GEM MAR00648Inferred only
- O-phosphoethanolamine is metabolised by CYP27A1ProteinHuman-GEM MAR04627Inferred only
- O-phosphoethanolamine is a substrate of ETNPPLProteinHuman-GEM MAR04296Inferred only
- O-phosphoethanolamine is a substrate of PCYT2ProteinHuman-GEM MAR00651Inferred only
- O-phosphoethanolamine is a substrate of PHOSPHO1ProteinHuman-GEM MAR00649Inferred only
- O-phosphoethanolamine is a substrate of SGPL1ProteinHuman-GEM MAR00748Inferred only
Reactions
14 reactions
ATP+ethanolamineADP+O-phosphoethanolamine+proton
Catalysed by CHKB or CHKA or ETNK1 or ETNK2
Reaction pageLeft to rightBalancedEC 2.7.1.82cytosol
Human-GEM MAR00648CC BY 4.0Reference data
O-phosphoethanolamine+waterethanolamine+phosphate(3-)
Catalysed by PHOSPHO1
Reaction pageLeft to rightBalancedEC 3.1.3.75cytosol
Human-GEM MAR00649CC BY 4.0Reference data
CHEBI:17677+O-phosphoethanolamine+protonCDP-ethanolamine+diphosphate(3-)
Catalysed by PCYT2
Reaction pageLeft to rightBalancedEC 2.7.7.14cytosol
Human-GEM MAR00651CC BY 4.0Reference data
O-phosphoethanolamine+hexadecanalsphinganine 1-phosphate
Catalysed by SGPL1
Reaction pageLeft to rightBalancedEC 4.1.2.27cytosol
Human-GEM MAR00748CC BY 4.0Reference data
sphingosine 1-phosphateO-phosphoethanolamine+(2E)-hexadecenal
Catalysed by SGPL1
Reaction pageLeft to rightBalancedEC 4.1.2.27cytosol
Human-GEM MAR00779CC BY 4.0Reference data
O-phosphoethanolamine+wateracetaldehyde+proton+ammonium+phosphate(3-)
Catalysed by ETNPPL
Reaction pageLeft to rightBalancedEC 4.2.3.2cytosol
Human-GEM MAR04296CC BY 4.0Reference data
O-phosphoethanolamine+S-adenosyl-L-methionineproton+MAM02600c+CHEBI:16680
Catalysed by CYP27A1
Reaction pageLeft to rightBalancedEC 2.1.1.103cytosol
Human-GEM MAR04627CC BY 4.0Reference data
1-(alk-1-enyl)-sn-glycero-3-phosphoethanolamine+waterMAM00224c+O-phosphoethanolamine+proton
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.38cytosol
Human-GEM MAR07606CC BY 4.0Reference data
sphinganine 1-phosphateO-phosphoethanolamine+hexadecanal
Catalysed by SGPL1
Reaction pageLeft to rightBalancedEC 4.1.2.27endoplasmic reticulum
Human-GEM MAR08237CC BY 4.0Reference data
water+sphingosine 1-phosphateO-phosphoethanolamine+proton+hexadecanoic acid
Catalysed by SGPL1
Reaction pageLeft to rightBalancedEC 4.1.2.27endoplasmic reticulum
Human-GEM MAR08238CC BY 4.0Reference data
O-phosphoethanolamineO-phosphoethanolamine
Reaction pageReversibleBalancedendoplasmic reticulum, cytosol
Human-GEM MAR09634CC BY 4.0Reference data
O-phosphoethanolamineO-phosphoethanolamine
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09827CC BY 4.0Reference data
On the label
Labelled products
2 products
Source: NIH DSLD · Ingredient: O-phosphoethanolamine · 2 products · Declared amount per serving: 952–952 mg (1 products)
1 label states an amount1 does not
- AB American BiologicsCalcium A.E.P.952 mgper 1 Capsule(s)DSLD:203331
- InterPlexusSeriphosamount not statedper 1 Vegetarian Capsule(s)DSLD:306838
Label record: NIH Office of Dietary Supplements · CC0
Other names
21 names
Resolves to: O-phosphoethanolamine
- Also called
- 2-amino-ethanol dihydrogen phosphate2-amino-ethanol phosphatecolamine phosphatecolamine phosphoric acidcolaminphosphoric acidEAPethanolamine acid phosphateethanolamine O-phosphateEthanolamine phosphatemono(2-aminoethyl) phosphatemonoaminoethyl phosphateO-phosphocolamineO-PhosphorylethanolamineOPEPEPEApEtNPhosphoethanolaminephosphoric acid 2-aminoethyl phenyl esterphosphoryl-ethanolamine
- Systematic name
- 2-aminoethyl dihydrogen phosphate