(9Z)-octadecenoyl-CoA

Three steps

• arachidonoyl-CoAReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by SCD, SCD5, ACOT7, BAAT and 11 morecytosolOne of 12 routes

• CHEBI:15519Reach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by SCD, SCD5, ACOT7, BAAT and 6 morecytosol, peroxisomeOne of 2 routes

• phenylacetyl-CoAReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. Phenylacetate:CoA ligase

  Catalysed by SCD, SCD5, ACOT7, BAAT and 3 morecytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by SCD, SCD5, ACOT7, BAAT and 6 morecytosolOne of 45 routes

• CHEBI:15570Reach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 2 moreextracellular space, cytosolOne of 2 routes

• L-leucineReach from here →
  1. (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
  2. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate
  3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

  Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 5 moreOne of 6 routes

• CHEBI:15611Reach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 morecytosol

• a 1-hexadecanoyl-2-acylglycerolReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  3. a 2-acylglycerol + hexadecanoyl-CoA = a 1-hexadecanoyl-2-acylglycerol + CoA

  Catalysed by LPCAT3, MBOAT1, MBOAT2, LPCAT2 and 2 more

• an hexadecanoyl-acylglycerolReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  3. a 1-acylglycerol + hexadecanoyl-CoA = an hexadecanoyl-acylglycerol + CoA

  Catalysed by LPCAT3, MBOAT1, MBOAT2, LPCAT2 and 2 more

• 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  3. 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by LPCAT3, MBOAT1, MBOAT2, LPCAT2 and 2 more

• CHEBI:15650Reach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by SCD, SCD5, ACOT7, BAAT and 35 morecytosolOne of 2 routes

• CHEBI:15699Reach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 moreextracellular space, cytosolOne of 4 routes

• CHEBI:15727Reach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by SCD, SCD5, ACOT7, BAAT and 4 morecytosol

• CHEBI:15746Reach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by SCD, SCD5, ACOT7, BAAT and 5 morecytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Beta Oxidation of Long Chain Fatty Acid
  3. Palmitoyl-CoA hydrolase

  Catalysed by SCD, SCD5, ACAA1, HSD17B4 and 7 moreperoxisome, cytosolOne of 16 routes

• 1-acylglycerone 3-phosphateReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:glycerone-phosphate O-acyltransferase

  Catalysed by SCD, SCD5, GNPATcytosol

• CHEBI:15971Reach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. transport of glycine and histidine (cytosol to extracellular)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 moreextracellular space, cytosolOne of 2 routes

• phosphatidylethanolamineReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

  Catalysed by SCD, SCD5, LPCAT4, LPCAT3 and 3 morecytosol

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by SCD, SCD5, LPCAT4, LPCAT3 and 2 morecytosol

• hexadecan-1-olReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Beta Oxidation of Long Chain Fatty Acid
  3. formate dehydrogenase (palmitoyl-CoA)

  Catalysed by SCD, SCD5, ACAA1, HSD17B4 and 4 moreperoxisomeOne of 2 routes

• 11-cis-retinyl hexadecanoateReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Beta Oxidation of Long Chain Fatty Acid
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by SCD, SCD5, ACAA1, HSD17B4 and 7 moreperoxisome, cytosolOne of 2 routes

• 11-cis-retinolReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by SCD, SCD5, ACOT7, BAAT and 8 morecytosol

• phosphatidic acidReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. acyl-CoA pool formation and breakdown
  3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by SCD, SCD5, AGPAT2, LCLAT1 and 7 morecytosol, mitochondrial matrixOne of 7 routes

• L-citrullineReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 3 moreextracellular space, cytosol

• L-valineReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. transport of glycine and valine (cytosol to extracellular)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 moreextracellular space, cytosolOne of 4 routes

• oxaloacetateReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. ATP citrate lyase (citrate)

  Catalysed by SCD, SCD5, ACOT7, BAAT and 4 morecytosol

• L-arginineReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 2 moreextracellular space, cytosolOne of 2 routes

• protein polypeptide chainReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. PROTEIN_BS

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1cytosol

• pregnenoloneReach from here →
  1. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
  2. Steryl-ester acylhydrolase
  3. cytochrome P450 (cholesterol)

  Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 morelysosome, mitochondrial matrixOne of 2 routes

• CHEBI:16856Reach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 morecytosol

• CHEBI:16857Reach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 3 moreextracellular space, cytosolOne of 4 routes

• sn-glycerol 3-phosphocholineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)

  Catalysed by LPCAT3, MBOAT1, MBOAT2, LPCAT2 and 18 moreOne of 14 routes

• glyoxylic acidReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 moreperoxisome

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. glycerol-3-phosphate 1-O-acyltransferase (sn-glycerol-3-phosphate)
  3. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation

  Catalysed by SCD, SCD5, GPAT3, GPAT2 and 2 morecytosolOne of 17 routes

• octadecanalReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. octadecanal + NAD(+) + H2O = octadecanoate + NADH + 2 H(+)

  Catalysed by SCD, SCD5, ACOT7, BAAT and 4 morecytosol

• L-isoleucineReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 moreextracellular space, cytosolOne of 4 routes

• CHEBI:17203Reach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. transport of glycine and proline (cytosol to extracellular)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 2 moreextracellular space, cytosolOne of 2 routes

• CHEBI:17208Reach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. N-(9Z-octadecenoyl)glycine + 2 L-ascorbate + O2 = N-(9Z-octadecenoyl)-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  3. 12,13-epoxy-9-hydroperoxy... to 12,13-epoxylinoleic acid-radical conversion

  Catalysed by GLYATL3, GLYATL2, PAMcytosolOne of 3 routes

• dehydroascorbic acidReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. N-(9Z-octadecenoyl)glycine + 2 L-ascorbate + O2 = N-(9Z-octadecenoyl)-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  3. prostaglandin-F synthase (monodehydroascorbate)

  Catalysed by GLYATL3, GLYATL2, PAMcytosolOne of 2 routes

• anilineReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by SCD, SCD5, ACOT7, BAAT and 5 morecytosol

• CHEBI:17312Reach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by SCD, SCD5, ACOT7, BAAT and 3 morecytosolOne of 2 routes

• linoleic acidReach from here →
  1. (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 4 morecytosol, extracellular spaceOne of 14 routes

• D-glyceraldehydeReach from here →
  1. 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA
  2. 1-(9Z-octadecenoyl)-glycerol + 1,2-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol
  3. glycerol + NADP(+) = D-glyceraldehyde + NADPH + H(+)

  Catalysed by DGAT1, MOGAT2, AWAT2, DGAT2L6 and 7 more

• a monoacylglycerolReach from here →
  1. 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA
  2. 1-(9Z-octadecenoyl)-glycerol + 1,2-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol
  3. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)

  Catalysed by DGAT1, MOGAT2, AWAT2, DGAT2L6 and 6 more

• 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase

  Catalysed by SCD, SCD5, LPCAT4, LPCAT3 and 2 morecytosol

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Beta Oxidation of Long Chain Fatty Acid
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by SCD, SCD5, ACAA1, HSD17B4 and 4 moreperoxisomeOne of 18 routes

• cholesteryl 3-beta-D-glucosideReach from here →
  1. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
  2. cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)
  3. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine

  Catalysed by SOAT2, SOAT1, CEL, CES1 and 5 moreOne of 7 routes

• 7alpha-hydroxycholesterolReach from here →
  1. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
  2. Steryl-ester acylhydrolase
  3. cytochrome P450 (cholesterol)

  Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 morelysosome, endoplasmic reticulumOne of 2 routes

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
  2. Steryl-ester acylhydrolase
  3. Phosphatidylcholine:sterol O-acyltransferase

  Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 morelysosome, cytosolOne of 2 routes