(5-hydroxyindol-3-yl)acetaldehyde

Three steps

• quinolinic acidReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. Transport of Quinolinic Acid

  Catalysed by ALDH2, ALDH1B1, SLC4A1, SLC22A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• melatoninReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. S-adenosyl-L-homocysteine:N-acetylserotonin O-methyltransferase

  Catalysed by MAOA, AANAT, ASMTcytosol

• bilirubin IXalphaReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of bilirubin (cytosol to extracellular)

  Catalysed by MAOA, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• oxalic acidReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. transport of oxalate and sulfate (cytosol to extracellular)

  Catalysed by ALDH2, ALDH1B1, SLC4A1, SLC26A6mitochondrial matrix, extracellular space, cytosol

• taurolithocholateReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by MAOA, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• CHEBI:17208Reach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. glutathione:dehydroascorbate oxidoreductase

  Catalysed by MAOA, SLCO1A2, SLCO1B3extracellular space, cytosol

• homocysteineReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. Formation of Homocystine

  Catalysed by MAOA, SLCO1A2, SLCO1B3extracellular space, cytosol

• anilineReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by MAOA, AANAT, NAT2, NAT1cytosol

• CHEBI:17312Reach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by MAOA, AANATcytosolOne of 2 routes

• sulfiteReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)

  Catalysed by ALDH2, ALDH1B1, SLC4A1, SLC25A14 and 1 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-aspartic acidReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of D-aspartate (cytosol to extracellular)

  Catalysed by MAOA, SLC6A4, SLC1A7, SLC1A3 and 3 moreextracellular space, cytosol

• L-cysteineReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by MAOA, AANAT, NAGScytosol, mitochondrial matrixOne of 4 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. Steryl-Sulfatase

  Catalysed by ALDH2, ALDH1B1, SLC4A1, STSmitochondrial matrix, extracellular space, cytosol, Golgi apparatusOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by MAOA, AANAT, HADHA, ACADVL and 1 morecytosol, mitochondrial matrix

• CHEBI:17927Reach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by MAOA, AANATcytosol

• fumaric acidReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. transport of fumarate and sulfate (cytosol to mitochondria)

  Catalysed by ALDH2, ALDH1B1, SLC4A1, SLC25A10mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by MAOA, AANAT, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by MAOA, AANAT, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by MAOA, AANAT, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by MAOA, AANAT, HADHA, ACADVL and 1 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by MAOA, AANAT, HADHA, ACADVL and 1 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by MAOA, AANAT, ECHS1, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by MAOA, AANAT, ECHS1, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• folic acidReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. Folate Transport by Oats

  Catalysed by ALDH2, ALDH1B1, SLC4A1, SLC22A8 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• CHEBI:27540Reach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by MAOA, AANAT, ACSM4, ACSM1 and 4 morecytosolOne of 6 routes

• elaidic acidReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by MAOA, AANAT, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• 5(S)-HETEReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by MAOA, SLCO1A2, SLCO1B3, GPX5 and 8 moreextracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of LTD4 (cytosol to extracellular)

  Catalysed by MAOA, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• CHEBI:28701Reach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by MAOA, AANAT, ACAA1, SCP2 and 1 morecytosol, peroxisomeOne of 7 routes

• a dicarboxylateReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by ALDH2, ALDH1B1, SLC4A1, SLC25A35 and 1 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• Ca(2+)Reach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of Ca2+ and K+ (cytosol to extracellular)

  Catalysed by MAOA, SLC6A4, SLC24A1, SLC24A5 and 3 moreextracellular space, cytosolOne of 3 routes

• chlorine(.)Reach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by ALDH2, ALDH1B1, SLC4A1, SLC26A6mitochondrial matrix, extracellular space, cytosolOne of 3 routes

• glycocholateReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. solute carrier organic anion transporter (glycocholate)

  Catalysed by MAOA, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• cholateReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by MAOA, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• D-aspartateReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by ALDH2, ALDH1B1, SLC4A1, SLC25A14 and 1 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-aspartateReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)

  Catalysed by ALDH2, ALDH1B1, SLC4A1, SLC25A14 and 1 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• oxalateReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by ALDH2, ALDH1B1, SLC4A1, SLC25A14 and 4 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• maleateReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by ALDH2, ALDH1B1, SLC4A1, SLC25A14 and 1 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• malonic acidReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. transport of malonate and sulfate (cytosol to mitochondria)

  Catalysed by ALDH2, ALDH1B1, SLC4A1, SLC25A10mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• (2R,3R)-tartrateReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by ALDH2, ALDH1B1, SLC4A1, SLC25A14 and 1 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by ALDH2, ALDH1B1, SLC4A1, SLC25A14 and 1 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by ALDH2, ALDH1B1, SLC4A1, SLC25A14 and 1 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by ALDH2, ALDH1B1, SLC4A1, SLC25A14 and 1 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of arachidonate (cytosol to extracellular)

  Catalysed by MAOA, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• thiosulfateReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)

  Catalysed by ALDH2, ALDH1B1, SLC4A1, SLC25A14 and 3 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• chenodeoxycholateReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by MAOA, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• taurocholateReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by MAOA, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glycolithocholic acidReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of glycolithocholate (cytosol to extracellular)

  Catalysed by MAOA, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• gamma-Glu-AlaReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by MAOA, SLCO1A2, SLCO1B3, GGT1 and 5 moreextracellular space, cytosol

• taurineReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by MAOA, AANAT, BAATcytosolOne of 2 routes