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Proteins/UNIPROT:O15121
Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Catalyzes the equilibrium isomerization of retinols (By similarity)..
Function from UniProtKB (O15121), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
1 row
87 statements
87 statements · 6 reference databases · Subject: DEGS1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
10 reactions
an N-acylsphinganine+proton+NADPH(4-)+dioxygenwater+NADP(3-)+an N-acyl-(4R)-4-hydroxysphinganine
Reaction pageLeft to rightBalance undeterminableEC 1.14.-.-cytosol
Human-GEM MAR00715CC BY 4.0Reference data
8 names
Resolves to: DEGS1
Reaction pageLeft to rightBalance undeterminableEC 1.14.-.-cytosol
Human-GEM MAR00754CC BY 4.0Reference data
an N-acylsphinganine+NADP(3-)an N-acylsphing-4-enine+proton+NADPH(4-)
Reaction pageLeft to rightBalance undeterminablecytosol
Human-GEM MAR08219CC BY 4.0Reference data
an N-acylsphinganine+FADan N-acylsphing-4-enine+FADH2
Reaction pageLeft to rightBalance undeterminablecytosol
Human-GEM MAR08220CC BY 4.0Reference data
all-trans-retinol11-cis-retinol
Catalysed by DEGS1
Reaction pageReversibleBalanced
Rhea RHEA:19141CC BY 4.0Reference data
an N-acylsphinganine+2Fe(II)-[cytochrome b5]+dioxygen+2hydronan N-acylsphing-4-enine+2Fe(III)-[cytochrome b5]+2water
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:46544CC BY 4.0Reference data
all-trans-retinol9-cis-retinol
Catalysed by DEGS1
Reaction pageLeft to rightBalanced
Rhea RHEA:55348CC BY 4.0Reference data
all-trans-retinol13-cis-retinol
Catalysed by DEGS1
Reaction pageLeft to rightBalanced
Rhea RHEA:55352CC BY 4.0Reference data
Catalysed by DEGS1
Reaction pageLeft to rightBalanced
Rhea RHEA:55356CC BY 4.0Reference data
Catalysed by DEGS1
Reaction pageLeft to rightBalanced
Rhea RHEA:55360CC BY 4.0Reference data