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Proteins/UNIPROT:Q6QHC5
Bifunctional enzyme which acts both as a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase..
Function from UniProtKB (Q6QHC5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
31 statements
31 statements · 6 reference databases · Subject: DEGS2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
9 reactions
an N-acylsphinganine+proton+NADPH(4-)+dioxygenwater+NADP(3-)+an N-acyl-(4R)-4-hydroxysphinganine
Reaction pageLeft to rightBalance undeterminableEC 1.14.-.-cytosol
Human-GEM MAR00715CC BY 4.0Reference data
5 names
Resolves to: DEGS2
Reaction pageLeft to rightBalance undeterminableEC 1.14.-.-cytosol
Human-GEM MAR00754CC BY 4.0Reference data
an N-acylsphinganine+NADP(3-)an N-acylsphing-4-enine+proton+NADPH(4-)
Reaction pageLeft to rightBalance undeterminablecytosol
Human-GEM MAR08219CC BY 4.0Reference data
an N-acylsphinganine+FADan N-acylsphing-4-enine+FADH2
Reaction pageLeft to rightBalance undeterminablecytosol
Human-GEM MAR08220CC BY 4.0Reference data
an N-acylsphinganine+proton+NADPH(4-)+dioxygenwater+NADP(3-)+MAM03863c
Catalysed by DEGS2
Reaction pageLeft to rightBalance undeterminablecytosol
Human-GEM MAR12041CC BY 4.0Reference data
CHEBI:82841+2Fe(II)-[cytochrome b5]+dioxygen+2hydronCHEBI:82842+2Fe(III)-[cytochrome b5]+water
Catalysed by DEGS2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:43116CC BY 4.0Reference data
an N-acylsphinganine+2Fe(II)-[cytochrome b5]+dioxygen+2hydronan N-acyl-(4R)-4-hydroxysphinganine+2Fe(III)-[cytochrome b5]+water
Catalysed by DEGS2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:46364CC BY 4.0Reference data
an N-acylsphinganine+2Fe(II)-[cytochrome b5]+dioxygen+2hydronan N-acylsphing-4-enine+2Fe(III)-[cytochrome b5]+2water
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:46544CC BY 4.0Reference data
CHEBI:139048+2Fe(II)-[cytochrome b5]+dioxygen+2hydronCHEBI:139051+2Fe(III)-[cytochrome b5]+water
Catalysed by DEGS2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:55808CC BY 4.0Reference data