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Reach

S-methylmercury-L-cysteine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

394 compounds within 3 steps: 3 in 1, 48 in 2, 343 in 3

Does it reach a compound?

Two steps

L-methionine (R)-S-oxideReach from here →
1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
2. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol
Catalysed by SLC7A8, MSRB3, MSRB1, MSRB2inner side of the membrane, outer side of the membrane

Three steps

beta-carbolineReach from here →
Catalysed by SLC7A8, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosol
(S)-carnitineReach from here →
Catalysed by and 1 more

Page 2 of 8

SLC7A8

, NAGS

, CPT1A

, CPT1C

inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

One of 245 routes

N(omega)-methyl-L-arginineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of glycine and methionine (cytosol to extracellular)
N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

Catalysed by SLC7A8, SLC7A5, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

3-methyl-2-oxobutanoateReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of methionine and valine (cytosol to extracellular)
L-Valine:2-oxoglutarate aminotransferase

Catalysed by SLC7A8, SLC7A5, BCAT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 3 routes

(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphateReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)

Catalysed by SLC7A8, CDKAL1, MOCS1inner side of the membrane, outer side of the membrane

AReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of cysteine and methionine (cytosol to extracellular)
Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by SLC7A8, SLC7A5, MOCOSinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 71 routes

glycoursodeoxycholateReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of glycine and methionine (cytosol to extracellular)
glycine to glycoursodeoxycholate conversion

Catalysed by SLC7A8, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O

Catalysed by SLC7A8, CDKAL1, PTGS2inner side of the membrane, outer side of the membrane

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O

Catalysed by SLC7A8, CDKAL1, PTGS2inner side of the membrane, outer side of the membrane

prostaglandin H3Reach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
prostaglandin G3 + AH2 = prostaglandin H3 + A + H2O

Catalysed by SLC7A8, CDKAL1, PTGS2inner side of the membrane, outer side of the membrane

epsilon-(gamma-L-glutamyl)-L-lysineReach from here →

S-methylmercury-L-cysteine(in) + L-leucine(out) = S-methylmercury-L-cysteine(out) + L-leucine(in)
L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)
epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine

Catalysed by SLC7A8, SLC7A7, GGACTinner side of the membrane, outer side of the membrane

13-hydroxy-(9Z,11E)-octadecadienoateReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O

Catalysed by SLC7A8, CDKAL1, PTGS2inner side of the membrane, outer side of the membrane

9-hydroxy-(10E,12Z)-octadecadienoateReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
(9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O

Catalysed by SLC7A8, CDKAL1, PTGS2inner side of the membrane, outer side of the membrane

N-(9Z-octadecenoyl)glycineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of glycine and methionine (cytosol to extracellular)
(9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

Catalysed by SLC7A8, SLC7A5, GLYATL3, GLYATL2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

N-octadecanoylglycineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of glycine and methionine (cytosol to extracellular)
octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

Catalysed by SLC7A8, SLC7A5, GLYATL2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

N-(9Z-hexadecenoyl)-glycineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of glycine and methionine (cytosol to extracellular)
(9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

Catalysed by SLC7A8, SLC7A5, GLYATL2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

(13R)-hydroxy-(9Z,11E)-octadecadienoateReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
(9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O

Catalysed by SLC7A8, CDKAL1, PTGS1, PTGS2inner side of the membrane, outer side of the membrane

2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by SLC7A8, CDKAL1, PTGS2inner side of the membrane, outer side of the membrane

2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by SLC7A8, CDKAL1, PTGS2inner side of the membrane, outer side of the membrane

2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by SLC7A8, CDKAL1, PTGS2inner side of the membrane, outer side of the membrane

2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O

Catalysed by SLC7A8, CDKAL1, PTGS2inner side of the membrane, outer side of the membrane

2-(prostaglandin H2)-sn-glycero-3-phosphocholineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O

Catalysed by SLC7A8, CDKAL1, PTGS2inner side of the membrane, outer side of the membrane

N-hexadecanoylglycineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of glycine and methionine (cytosol to extracellular)
hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

Catalysed by SLC7A8, SLC7A5, GLYATL3inner side of the membrane, outer side of the membrane, extracellular space, cytosol

N-dodecanoylglycineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of glycine and methionine (cytosol to extracellular)
dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

Catalysed by SLC7A8, SLC7A5, GLYATL2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

N-decanoylglycineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of glycine and methionine (cytosol to extracellular)
decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

Catalysed by SLC7A8, SLC7A5, GLYATL2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

N-octanoylglycineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of glycine and methionine (cytosol to extracellular)
octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

Catalysed by SLC7A8, SLC7A5, GLYATL2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

D-histidineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of methionine and ornithine (cytosol to extracellular)
D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)

Catalysed by SLC7A8, SLC7A6, SLC25A2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

L-homoarginineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of arginine and methionine (cytosol to extracellular)
L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)

Catalysed by SLC7A8, SLC7A6, SLC25A29inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

L-homocarnosineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of histidine and methionine (cytosol to extracellular)
Formation of homocarnosine

Catalysed by SLC7A8, SLC7A6, CARNS1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of glycine and methionine (cytosol to extracellular)
5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

Catalysed by SLC7A8, SLC7A5, GARTinner side of the membrane, outer side of the membrane, extracellular space, cytosol

L-cystine-bis-glycineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of glycine and methionine (cytosol to extracellular)
L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

Catalysed by SLC7A8, SLC7A5, DPEP1, DPEP2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

glycyldehydrophenylalanineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of glycine and methionine (cytosol to extracellular)
glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

Catalysed by SLC7A8, SLC7A5, DPEP1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of glutamine and methionine (cytosol to extracellular)
N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

Catalysed by SLC7A8, SLC7A5, PFASinner side of the membrane, outer side of the membrane, extracellular space, cytosol

kinetensin-(1-8)Reach from here →

S-methylmercury-L-cysteine(in) + L-leucine(out) = S-methylmercury-L-cysteine(out) + L-leucine(in)
Chymase
kinetensin + H2O = kinetensin-(1-8) + L-leucine

Catalysed by SLC7A8, CMA1, ACE2inner side of the membrane, outer side of the membrane, extracellular space

an N-(fatty acyl)-glycineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of glycine and methionine (cytosol to extracellular)
a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

Catalysed by SLC7A8, SLC7A5, GLYATL2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

N-(9Z,12Z-octadecadienoyl)-glycineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of glycine and methionine (cytosol to extracellular)
(9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

Catalysed by SLC7A8, SLC7A5, GLYATL2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

(7Z)-octadecenoyl-CoAReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N-acetylglutamate synthase (N-acetylmethionine)
carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

Catalysed by SLC7A8, NAGS, CPT1A, CPT1C and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 3 routes

acetaldehydeReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of methionine and threonine (cytosol to extracellular)
L-threonine acetaldehyde-lyase (glycine-forming)

Catalysed by SLC7A8, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosol

CHEBI:15345Reach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N-acetylglutamate synthase (N-acetylmethionine)
Acetoacetate:CoA ligase (AMP-forming)

Catalysed by SLC7A8, NAGS, AACSinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

cholineReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N-acetylglutamate synthase (N-acetylmethionine)
Acetyl-CoA:choline O-acetyltransferase

Catalysed by SLC7A8, NAGS, CHATinner side of the membrane, outer side of the membrane, mitochondrial matrix, nucleusOne of 2 routes

pyruvateReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
transport of alanine and methionine (cytosol to extracellular)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

Catalysed by SLC7A8, SLC7A5, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 17 routes

CHEBI:15380Reach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N-acetylglutamate synthase (N-acetylmethionine)
5-aminolevulinate synthase (2-amino-3-oxoadipate)

Catalysed by SLC7A8, NAGS, ALAS1, CPNE7inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 8 routes

CHEBI:15477Reach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N-acetylglutamate synthase (N-acetylmethionine)
glycine N-acyltransferase (2-methylbutyryl-CoA)

Catalysed by SLC7A8, NAGS, GLYAT, GLYATL2 and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

2-methylcrotonoyl-CoAReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N-acetylglutamate synthase (N-acetylmethionine)
Production of Tiglylcarnitine

Catalysed by SLC7A8, NAGS, CPT1A, CPT1Binner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

isobutyryl-CoAReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N-acetylglutamate synthase (N-acetylmethionine)
acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

Catalysed by SLC7A8, NAGS, HADHA, ACAA2 and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 3 routes

3-methylbut-2-enoyl-CoAReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N-acetylglutamate synthase (N-acetylmethionine)
glycine-N-acyltransferase (3-methylcrotonoylglycine)

Catalysed by SLC7A8, NAGS, GLYATinner side of the membrane, outer side of the membrane, mitochondrial matrix

isovaleryl-CoAReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N-acetylglutamate synthase (N-acetylmethionine)
glycine N-acyltransferase (isovalerylglycine)

Catalysed by SLC7A8, NAGS, GLYAT, GLYATL2 and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 3 routes

arachidonoyl-CoAReach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N-acetylglutamate synthase (N-acetylmethionine)
Arachidonate:CoA ligase (AMP-forming)

Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 11 routes

CHEBI:15519Reach from here →

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
N-acetylglutamate synthase (N-acetylmethionine)
propanoyl-CoA C-acyltransferase

Catalysed by SLC7A8, NAGS, ACAA1, SCP2 and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, peroxisomeOne of 2 routes