3-phenylpyruvate

Three steps

• (3S)-citramalyl-CoAReach from here →
  1. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by AADAT, AGXT, AGXT2, CLYBL

• L-2-aminoadipateReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. Transport of L-Kynurenine
  3. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O

  Catalysed by GOT2, TAT, SLC7A8, AADATmitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 5-phospho-beta-D-ribosylamineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. phosphoribosyl pyrophosphate amidotransferase (glutamine)

  Catalysed by GOT2, TAT, SLC7A5, PPATmitochondrial matrix, extracellular space, cytosolOne of 2 routes

• D-glucosamine 6-phosphateReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

  Catalysed by GOT2, TAT, SLC7A5, GFPT2 and 1 moremitochondrial matrix, extracellular space, cytosol

• L-methionine (S)-S-oxideReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by GOT2, TAT, SLC7A5, MSRAmitochondrial matrix, extracellular space, cytosol

• L-methionine (R)-S-oxideReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by GOT2, TAT, SLC7A5, MSRB3 and 2 moremitochondrial matrix, extracellular space, cytosol

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by GOT2, TAT, SLC7A5, GLYATL2mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by GOT2, TAT, SLC7A5, PPCSmitochondrial matrix, extracellular space, cytosolOne of 4 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by GOT2, TAT, PAH, TPH1 and 1 moremitochondrial matrixOne of 5 routes

• 2-hydroxy-4-methylvaleric acidReach from here →
  1. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  2. L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine
  3. 4-methyl-2-oxopentanoate reduction

  Catalysed by AADAT, SDR42E2, AKR1B15, AKR1B10 and 15 morecytosol

• an L-alpha-amino acidReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. Transport of L-Kynurenine
  3. an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)

  Catalysed by GOT2, TAT, SLC7A8, SLC7A11mitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-aminobutanoateReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by GOT2, TAT, SLC6A14, SLC6A12mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• 3-iodo-L-tyrosineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of phenylalanine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by GOT2, TAT, SLC7A5, TPOmitochondrial matrix, extracellular space, cytosolOne of 2 routes

• dopamineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  3. L-dopa + H(+) = dopamine + CO2

  Catalysed by GOT2, TAT, SLC7A8, DDCmitochondrial matrix, inner side of the membrane, outer side of the membrane

• L-prolineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by GOT2, TAT, SLC7A5, SLC1A4mitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• estrone 3-sulfateReach from here →
  1. 3-phenylpyruvate + L-kynurenine = kynurenate + L-phenylalanine + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6, SLC22A24, SLC22A8 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin E2Reach from here →
  1. 3-phenylpyruvate + L-kynurenine = kynurenate + L-phenylalanine + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. prostaglandin E2(out) + glutarate(in) = prostaglandin E2(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 4 routes

• N-benzoylglycineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by GOT2, TAT, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• 3-sulfino-L-alanineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by GOT2, TAT, SLC7A5, CDO1mitochondrial matrix, extracellular space, cytosolOne of 6 routes

• L-cysteinylglycineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by GOT2, TAT, SLC7A5, GGTLC3 and 5 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

  Catalysed by GOT2, TAT, SLC7A6, NOS3 and 2 moremitochondrial matrix, extracellular space, cytosol

• Mo-molybdopterinReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by GOT2, TAT, SLC7A5, MOCOSmitochondrial matrix, extracellular space, cytosol

• (2S)-2-aminobutanoateReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by GOT2, TAT, SLC7A5, AGXT2mitochondrial matrix, extracellular space, cytosolOne of 8 routes

• 2-iminobutanoateReach from here →
  1. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)

  Catalysed by AADAT, AGXT2, RIDA

• thio-Mo-molybdopterinReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by GOT2, TAT, SLC7A5, MOCOSmitochondrial matrix, extracellular space, cytosol

• 17beta-estradiol 17-O-(beta-D-glucuronate)Reach from here →
  1. 3-phenylpyruvate + L-kynurenine = kynurenate + L-phenylalanine + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• glycodeoxycholateReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. Glycodeoxycholate amidohydrolase

  Catalysed by GOT2, TAT, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• N-tetradecanoylglycineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by GOT2, TAT, SLC7A5, GLYATL2mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• N-eicosanoylglycinateReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by GOT2, TAT, SLC7A5, BAATmitochondrial matrix, extracellular space, cytosol

• N-docosanoylglycineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by GOT2, TAT, SLC7A5, BAATmitochondrial matrix, extracellular space, cytosol

• N-hexacosanoylglycineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by GOT2, TAT, SLC7A5, BAATmitochondrial matrix, extracellular space, cytosol

• an N(2)-acyl-L-glutamineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by GOT2, TAT, SLC7A5, GLYATL1B and 1 moremitochondrial matrix, extracellular space, cytosol

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by AADAT, AGXT, AGXT2, PDHA1 and 2 moremitochondrial matrix