cholesterol sulfate

Three steps

• glutathione disulfideReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by STS, SLC25A14, SLC25A30, SLC26A1 and 2 morecytosol, inner side of the membrane, outer side of the membrane

• L-tyrosineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)

  Catalysed by STS, SLC25A14, SLC25A30, SLC7A13cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by STS, SLC25A14, SLC25A30, AGXT2cytosol, inner side of the membrane, outer side of the membrane

• an acyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by STS, SOAT2, SOAT1, ASAH1 and 3 morecytosol, endoplasmic reticulum, Golgi apparatusOne of 2 routes

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by STS, SLC25A10, ADSLcytosol, mitochondrial matrixOne of 4 routes

• kynurenateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A8cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by STS, SOAT2, SOAT1, HADHA and 2 morecytosol, endoplasmic reticulum, mitochondrial matrixOne of 3 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Acyl-CoA:cholesterol O-acyltransferase
  3. Steryl-ester acylhydrolase

  Catalysed by STS, SOAT2, SOAT1, CEL and 1 morecytosol, endoplasmic reticulum, lysosomeOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 1 morecytosol, endoplasmic reticulumOne of 3 routes

• D-glucosamineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by STS, SGSHcytosol

• deoxycholoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 1 morecytosol, endoplasmic reticulumOne of 4 routes

• S-sulfanylglutathioneReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)

  Catalysed by STS, SLC25A14, SLC25A30, ETHE1cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-aminobutanoateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A12cytosol, extracellular spaceOne of 4 routes

• prostaglandin E2Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-benzoylglycineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)

  Catalysed by STS, SLC25A14, SLC25A30, SLC25A12 and 1 morecytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 4 routes

• decanoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by STS, SOAT2, SOAT1, ACSM4 and 5 morecytosol, endoplasmic reticulumOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by STS, SOAT2, SOAT1, CPT1A and 2 morecytosol, endoplasmic reticulumOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 11 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by STS, SOAT2, SOAT1, CPT1A and 1 morecytosol, endoplasmic reticulum

• CHEBI:63544Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 7 routes

• pregn-5-ene-3,20-dioneReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. cytochrome P450 (cholesterol)
  3. Pregnenolone:NAD+ 3-oxidoreductase

  Catalysed by STS, CYP11A1, HSD3B1, HSD3B2cytosol, mitochondrial matrixOne of 2 routes

• 4-methylpentan-1-olReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. cytochrome P450 (cholesterol)
  3. aldose reductase (isocaproic-aldehyde)

  Catalysed by STS, CYP11A1, AKR1B10, AKR1B1cytosol, mitochondrial matrixOne of 2 routes

• ubiquinol-10Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate

  Catalysed by STS, SLC25A14, SLC25A30, SQORcytosol, inner side of the membrane, outer side of the membrane

• hexacosanoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 10 routes

• docosanoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 9 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by STS, SOAT2, SOAT1, CPT1A and 2 morecytosol, endoplasmic reticulumOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 8 routes

• (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Acyl-CoA:cholesterol O-acyltransferase
  3. Steryl-ester acylhydrolase

  Catalysed by STS, SOAT2, SOAT1, CEL and 1 morecytosol, endoplasmic reticulum, lysosomeOne of 2 routes

• 1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Cytochrome P450, Family 46, Subfamily A, Polypeptide 1
  3. a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + (24S)-hydroxycholesterol = (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by STS, CYP46A1, LCATcytosol, endoplasmic reticulumOne of 2 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 5 routes

• nonadecanoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 6 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by STS, SOAT2, SOAT1, CPT1A and 2 morecytosol, endoplasmic reticulumOne of 3 routes

• dodecanedioyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Activation of dodecanedioic acid

  Catalysed by STS, SOAT2, SOAT1cytosol, endoplasmic reticulumOne of 4 routes