leukotriene F4

Three steps

• O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP

  Catalysed by SLCO1B1, UGT1A9, UGT2B7, UGT1A6 and 3 moreextracellular space, cytosol

• 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
  3. 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP + H(+)

  Catalysed by SLCO1B1, UGT2B7, UGT1A1, UGT1A4extracellular space, cytosol

• 15-O-(beta-D-glucuronosyl)-prostaglandin B1Reach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of prostaglandin B1 (cytosol to extracellular)
  3. prostaglandin B1 + UDP-alpha-D-glucuronate = 15-O-(beta-D-glucuronosyl)-prostaglandin B1 + UDP + H(+)

  Catalysed by SLCO1B1, UGT1A9, UGT2B7, UGT1A1 and 1 moreextracellular space, cytosol

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 8 routes

• serotonin O-sulfateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. serotonin + 3'-phosphoadenylyl sulfate = serotonin O-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 1 moreextracellular space, cytosol

• (R)-noradrenaline 4'-O-sulfateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of noradrenaline (cytosol to extracellular)
  3. sulfotransferase (noradrenaline)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3extracellular space, cytosolOne of 2 routes

• L-homocysteine thiolactoneReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. Formation of Homocystine
  3. arylesterase (homocysteine-thiolactone)

  Catalysed by PON1, PON2, PON3extracellular space, cytosol

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, mitochondrial matrixOne of 2 routes

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 1 morecytosol

• ursodeoxycholate 3-sulfateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. ursodeoxycholate + 3'-phosphoadenylyl sulfate = ursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• tauroursodeoxycholate 3-sulfateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. tauroursodeoxycholate + 3'-phosphoadenylyl sulfate = tauroursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• glycoursodeoxycholate 3-sulfateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of glycoursodeoxycholate (cytosol to extracellular)
  3. glycoursodeoxycholate + 3'-phosphoadenylyl sulfate = glycoursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• chenodeoxycholate 3-sulfateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)
  3. chenodeoxycholate + 3'-phosphoadenylyl sulfate = chenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• deoxycholateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (cholate)
  3. cytochrome P450 (cholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, CYP7A1extracellular space, cytosolOne of 4 routes

• CHEBI:240943Reach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrix

• a quinolReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 1 morecytosol

• potassium atomReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLC6A4extracellular space, cytosol

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamineReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. fatty acylamide amidohydrolase

  Catalysed by SLCO1B1, FAAHextracellular space, cytosol

• imidazole-4-acetaldehydeReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of histamine (cytosol to extracellular)
  3. amine oxidase copper containing (histamine)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, AOC2 and 2 moreextracellular space, cytosolOne of 2 routes

• phenylacetylglycineReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by GLYATcytosolOne of 3 routes

• CHEBI:27540Reach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 34 morecytosolOne of 6 routes

• 3,4-dihydroxyphenylacetaldehydeReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. monoamine oxidase (dopamine)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, AOC2 and 4 moreextracellular space, cytosolOne of 2 routes

• elaidic acidReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 5 routes

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  3. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase

  Catalysed by SLCO1B1, STSextracellular space, cytosolOne of 3 routes

• CHEBI:28701Reach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)
  3. chenodeoxycholate:CoA ligase (AMP-forming)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLC27A5extracellular space, cytosolOne of 10 routes

• CHEBI:28918Reach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of noradrenaline (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:phenylethanolamine N-methyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, PNMTextracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by NAGSextracellular space, cytosol, mitochondrial matrix

• a dicarboxylateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of prostaglandin E2 (cytosol to extracellular)
  3. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLC22A6extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• iron(2+)Reach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. glutathione:dehydroascorbate oxidoreductase
  3. cytochrome b reductase (ascorbate)

  Catalysed by CYBRD1extracellular space, cytosol

• L-ascorbic acidReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 3 morecytosol

• K(+)Reach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. serotonin(out) + K(+)(in) + Na(+)(out) + H(+)(in) = serotonin(in) + K(+)(out) + Na(+)(in) + H(+)(out)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLC6A4extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• Cys-tRNA(Cys)Reach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by CARS1extracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by GARS1cytosol

• chlorine(.)Reach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by SLC6A14extracellular space, cytosolOne of 5 routes

• hydrogen sulfideReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by CTHextracellular space, cytosolOne of 3 routes

• acetateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of acetylcholine (cytosol to extracellular)
  3. Acetylcholine aectylhydrolase

  Catalysed by SLCO1B1, SLCO1B3, BCHE, ACHEextracellular space, cytosolOne of 3 routes

• formic acidReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. alcohol dehydrogenase (formaldehyde)
  3. S-Formylglutathione hydrolase

  Catalysed by ADH1C, ADH1A, ADH5, ADH6 and 3 moreextracellular space, cytosol

• an alcoholReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 morecytosol

• glutarateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (glycocholate)
  3. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLC22A24extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 12 routes

• pentanoateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. pentanoate(in) + estrone 3-sulfate(out) = pentanoate(out) + estrone 3-sulfate(in)

  Catalysed by SLCO1B1, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• methylarsonateReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 moreextracellular space, cytosol

• thiosulfateReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 moreextracellular space, cytosolOne of 2 routes

• di-mu-sulfido-diiron(2+)Reach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. De novo synthesis of 2Fe2S

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 3 moreextracellular space, cytosol, mitochondrial matrix

• fatty acidReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

• 5-aminolevulinateReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by ALAS1, ALAS2cytosol

• glycochenodeoxycholateReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by BAATcytosolOne of 2 routes