N(omega)-methyl-L-arginine

1. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

Catalysed by AGXT2, AADAT

1. N(omega)-methyl-L-arginine(in) + L-arginine(out) = N(omega)-methyl-L-arginine(out) + L-arginine(in)
2. N(omega),N(omega)-dimethyl-L-arginine(in) + L-arginine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-arginine(in)

Catalysed by SLC25A29, SLC25A2inner side of the membrane, outer side of the membraneOne of 4 routes

1. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine
2. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

Catalysed by AGXT2, SLC1A4inner side of the membrane, outer side of the membraneOne of 2 routes

1. N(omega)-methyl-L-arginine(in) + L-arginine(out) = N(omega)-methyl-L-arginine(out) + L-arginine(in)
2. L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)

Catalysed by SLC25A29, IL4I1inner side of the membrane, outer side of the membrane

1. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

Catalysed by AGXT2, GLYATL2One of 2 routes

1. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine
2. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

Catalysed by AGXT2, SLC1A4inner side of the membrane, outer side of the membraneOne of 2 routes

1. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine
2. Hippurate (Benzoylglycinate) Formation

Catalysed by AGXT2mitochondrial matrixOne of 2 routes

1. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine
2. gamma-glutamyltransferase (alanine)

Catalysed by AGXT2, GGTLC3, GGT1, GGT5 and 3 morecytosolOne of 2 routes

1. N(omega)-methyl-L-arginine(in) + L-arginine(out) = N(omega)-methyl-L-arginine(out) + L-arginine(in)
2. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

Catalysed by SLC25A29, NOS3, NOS1, NOS2inner side of the membrane, outer side of the membrane, cytosol

1. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by AGXT2, MOCOS

1. N(omega)-methyl-L-arginine + H2O = L-citrulline + methylamine
2. (R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2

Catalysed by DDAH1, MAOA, MAOB

1. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

Catalysed by AGXT2One of 2 routes

1. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine
2. Glycodeoxycholate amidohydrolase

Catalysed by AGXT2cytosolOne of 2 routes

1. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

Catalysed by AGXT2, GLYATL2

1. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine
2. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

Catalysed by AGXT2, BAAT

1. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine
2. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

Catalysed by AGXT2, BAAT

1. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine
2. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

Catalysed by AGXT2, BAAT

1. N(omega)-methyl-L-arginine + H2O = L-citrulline + methylamine
2. transport of citrulline and tryptophan (cytosol to extracellular)
3. beta-carboline hydrolysis

Catalysed by DDAH1, SLC7A9, SLC3A1, SLC7A6extracellular space, cytosol

1. N(omega)-methyl-L-arginine(in) + L-arginine(out) = N(omega)-methyl-L-arginine(out) + L-arginine(in)
2. transport of arginine and chloride (cytosol to extracellular)
3. Carnitine Transport by Atb0