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Proteins/UNIPROT:Q9BSK2
Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports uridine, thymidine, guanosine, cytosine and inosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism. Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration. Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production. Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation..
Function from UniProtKB (Q9BSK2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
61 statements
61 statements · 4 reference databases · Subject: SLC25A33 · Sources: gene ontology, Hetionet, Human-GEM, Rhea
30 reactions
Transported by SLC25A33
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR08301CC BY 4.0Reference data
CHEBI:17677+UTPCHEBI:17677+UTP
Transported by SLC25A36 or SLC25A33
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR20146CC BY 4.0Reference data
5 names
Resolves to: SLC25A33
CHEBI:17239+UTPCHEBI:17239+UTP
Transported by SLC25A33
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR20152CC BY 4.0Reference data
Transported by SLC25A33
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR20153CC BY 4.0Reference data
Transported by SLC25A33
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR20154CC BY 4.0Reference data
Transported by SLC25A33
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR20155CC BY 4.0Reference data
Transported by SLC25A33
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR20156CC BY 4.0Reference data
CHEBI:16497+UTPCHEBI:16497+UTP
Transported by SLC25A33
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR20157CC BY 4.0Reference data
CHEBI:28862+UTPCHEBI:28862+UTP
Transported by SLC25A33
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR20158CC BY 4.0Reference data
CHEBI:16039+UTPCHEBI:16039+UTP
Transported by SLC25A33
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR20159CC BY 4.0Reference data
Transported by SLC25A33
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR20160CC BY 4.0Reference data
Transported by SLC25A33
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR20161CC BY 4.0Reference data