Proteins/UNIPROT:Q6ZSM3

SLC16A12

ProteinUNIPROT:Q6ZSM3Monocarboxylate transporter 12

Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution..

Function from UniProtKB (Q6ZSM3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

juvenile cataract-microcornea-renal glucosuria syndrome has a germline basis in SLC16A12DiseaseGenCC HGNC:23094|MONDO:0012786Inferred only

Statements

8 statements

8 statements · 3 reference databases · Subject: SLC16A12 · Sources: Hetionet, Human-GEM, Rhea

Order

C2orf69 covaries with SLC16A12ProteinHetionet hetionet:covaries:205327-387700Inferred only
DENND1C covaries with SLC16A12ProteinHetionet hetionet:covaries:387700-79958Inferred only
LRRC31 covaries with SLC16A12ProteinHetionet hetionet:covaries:387700-79782Inferred only
MS4A7 covaries with SLC16A12ProteinHetionet hetionet:covaries:387700-58475Inferred only
ZBED2 covaries with SLC16A12ProteinHetionet hetionet:covaries:387700-79413Inferred only
acetate is transported by SLC16A12CompoundHuman-GEM MAR05292Inferred only
creatine is transported by SLC16A12CompoundRhea RHEA:73043Inferred only
guanidinoacetate is transported by SLC16A12CompoundRhea RHEA:73047Inferred only

Reactions

3 reactions

acetateacetate
Transported by SLC16A12 or SLC16A13
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR05292CC BY 4.0Reference data
creatinecreatine
Transported by SLC16A12 or SLC16A9 or SLC22A15
Reaction pageRight to leftBalanced
Rhea RHEA:73043CC BY 4.0Reference data

Other names

5 names

Resolves to: SLC16A12

Also called: Creatine transporter 2CRT2MCT 12MCT12Solute carrier family 16 member 12

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