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Proteins/UNIPROT:Q96AB6
N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn..
Function from UniProtKB (Q96AB6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
47 statements
47 statements · 2 reference databases · Subject: NTAN1 · Sources: Hetionet, Human-GEM
4 reactions
2water+MAM02866cL-glutamate(1-)+glycine+MAM02867c
Catalysed by SIRT6 or SIRT1 or SIRT5 or OARD1 or ACY3 or MACROD1 or SIRT3 or NTAQ1 or NTAN1 or SIRT7
Reaction pageReversibleBalancedEC 3.5.1.-cytosol
Human-GEM MAR05336CC BY 4.0Reference data
12 names
Resolves to: NTAN1
water+MAM02548cacetate+MAM02867c
Catalysed by SIRT2 or SIRT6 or SIRT1 or SIRT5 or OARD1 or ACY3 or MACROD1 or NAAA or SIRT3 or NTAN1 or MACROD2 or SIRT7
Reaction pageReversibleBalancedEC 3.5.1.-cytosol
Human-GEM MAR05339CC BY 4.0Reference data
water+MAM02867cammonium+MAM02865c
Catalysed by SIRT2 or SIRT6 or SIRT1 or SIRT5 or OARD1 or ACY3 or NTAQ1 or NTAN1 or SIRT7
Reaction pageLeft to rightBalancedEC 3.5.1.-cytosol
Human-GEM MAR05340CC BY 4.0Reference data
N-terminal L-asparaginyl-[protein]+water+hydronN-terminal L-aspartyl-[protein]+ammonium
Catalysed by NTAN1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:50676CC BY 4.0Reference data