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Proteins/UNIPROT:Q9BQ69
Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity..
Function from UniProtKB (Q9BQ69), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
34 statements
34 statements · 5 reference databases · Subject: MACROD1 · Sources: Bgee, Hetionet, Human-GEM, Rhea, WikiPathways
10 reactions
2water+MAM02866cL-glutamate(1-)+glycine+MAM02867c
Catalysed by SIRT6 or SIRT1 or SIRT5 or OARD1 or ACY3 or MACROD1 or SIRT3 or NTAQ1 or NTAN1 or SIRT7
Reaction pageReversibleBalancedEC 3.5.1.-cytosol
Human-GEM MAR05336CC BY 4.0Reference data
6 names
Resolves to: MACROD1
water+MAM02548cacetate+MAM02867c
Catalysed by SIRT2 or SIRT6 or SIRT1 or SIRT5 or OARD1 or ACY3 or MACROD1 or NAAA or SIRT3 or NTAN1 or MACROD2 or SIRT7
Reaction pageReversibleBalancedEC 3.5.1.-cytosol
Human-GEM MAR05339CC BY 4.0Reference data
water+2''-O-acetyl-ADP-D-riboseacetate+ADP-D-ribose+proton
Catalysed by MACROD2 or MACROD1 or OARD1
Reaction pageLeft to rightBalancedEC 3.1.1.106nucleus
Human-GEM MAR20099CC BY 4.0Reference data
water+alpha-NAD(+)ADP-D-ribose+proton+nicotinamide
Catalysed by MACROD2 or MACROD1 or OARD1
Reaction pageLeft to rightBalancedEC 3.1.1.106nucleus
Human-GEM MAR20100CC BY 4.0Reference data
water+3''-O-acetyl-ADP-D-riboseacetate+ADP-D-ribose+proton
Catalysed by MACROD1
Reaction pageLeft to rightBalancedEC 3.1.1.106, 3.1.1.ynucleus
Human-GEM MAR20101CC BY 4.0Reference data
4-O-(ADP-D-ribosyl)-L-aspartyl-[protein]+waterL-aspartyl-[protein]+ADP-D-ribose+hydron
Catalysed by MACROD2 or MACROD1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54428CC BY 4.0Reference data
2''-O-acetyl-ADP-D-ribose+waterADP-D-ribose+acetate+hydron
Catalysed by MACROD2 or MACROD1 or OARD1
Reaction pageLeft to rightBalanced
Rhea RHEA:57060CC BY 4.0Reference data
5-O-(ADP-D-ribosyl)-L-glutamyl-[protein]+waterL-glutamyl-[protein]+ADP-D-ribose+hydron
Catalysed by MACROD2 or MACROD1 or OARD1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:58248CC BY 4.0Reference data
3''-O-acetyl-ADP-D-ribose+waterADP-D-ribose+acetate+hydron
Catalysed by MACROD1
Reaction pageLeft to rightBalanced
Rhea RHEA:59244CC BY 4.0Reference data
alpha-NAD(+)+waterADP-D-ribose+nicotinamide+hydron
Catalysed by MACROD2 or ADPRH or MACROD1 or ADPRS or OARD1
Reaction pageDirection not assertedBalanced
Rhea RHEA:68792CC BY 4.0Reference data