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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q99884

SLC6A7

Protein·UNIPROT:Q99884Sodium-dependent proline transporter1 compound

Open in the graph

Brain specific sodium (and chloride)-dependent proline transporter. Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals (Probable)..

Function from UniProtKB (Q99884), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · transported by

Inferred

Assembled routes, not reported.

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

sodium(1+)ElementCHEBI:29101Inferred only15 paths3 endpoints

What the reference databases state

Statements

24 statements

24 statements · 5 reference databases · Subject: SLC6A7 · Sources: Bgee, Human-GEM, Reactome, Rhea, WikiPathways

Search this listOrder

SLC6A7 is expressed in cerebellar cortexAnatomyBgee ENSG00000011083Inferred only
SLC6A7 is expressed in cerebellar hemisphereAnatomyBgee ENSG00000011083Inferred only
SLC6A7 is expressed in right hemisphere of cerebellumAnatomyBgee ENSG00000011083Inferred only
SLC6A7 participates in Creatine metabolismPathwayReactome R-HSA-71288Inferred only
SLC6A7 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
SLC6A7 participates in Metabolism of amino acids and derivativesPathwayReactome R-HSA-71291Inferred only
SLC6A7 participates in NRF2 pathwayPathwayWikiPathways WP2884Inferred only
SLC6A7 participates in Nuclear receptors meta pathwayPathwayWikiPathways WP2882Inferred only
SLC6A7 participates in SLC-mediated transmembrane transportPathwayReactome R-HSA-425407Inferred only
SLC6A7 participates in SLC-mediated transport of neurotransmittersPathwayReactome R-HSA-442660Inferred only
SLC6A7 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
CHEBI:17203 is transported by SLC6A7CompoundHuman-GEM MAR05322Inferred only

Show the remaining 12

CHEBI:17203 is transported by SLC6A7CompoundHuman-GEM MAR09617Inferred only
CHEBI:17203 is transported by SLC6A7CompoundHuman-GEM MAR08938Inferred only
chloride is transported by SLC6A7CompoundRhea RHEA:71267Inferred only
chloride is transported by SLC6A7CompoundRhea RHEA:71263Inferred only
chlorine(.) is transported by SLC6A7CompoundHuman-GEM MAR09617Inferred only
L-pipecolate is transported by SLC6A7CompoundRhea RHEA:71267Inferred only
L-proline is transported by SLC6A7CompoundRhea RHEA:71263Inferred only
sodium(1+) is transported by SLC6A7CompoundHuman-GEM MAR08938Inferred only
sodium(1+) is transported by SLC6A7CompoundHuman-GEM MAR05322Inferred only
sodium(1+) is transported by SLC6A7CompoundRhea RHEA:71263Inferred only
sodium(1+) is transported by SLC6A7CompoundRhea RHEA:71267Inferred only
sodium(1+) is transported by SLC6A7CompoundHuman-GEM MAR09617Inferred only

Reactions

5 reactions

sodium(1+)+CHEBI:17203sodium(1+)+CHEBI:17203
Transported by SLC6A7 or SLC6A15 or SLC38A1 or SLC38A2 or SLC38A4 or SLC6A20
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05322CC BY 4.0Reference data
2sodium(1+)+CHEBI:172032

Other names

3 names

Resolves to: SLC6A7

Also called: PROTSodium-dependent proline transporterSolute carrier family 6 member 7

← Every protein Find it in the graph →

Transported by SLC6A7

Reaction pageLeft to rightBalancedextracellular space, cytosol

Human-GEM MAR08938CC BY 4.0Reference data

chlorine(.)+sodium(1+)+CHEBI:17203chlorine(.)+sodium(1+)+CHEBI:17203

Transported by SLC6A7

Reaction pageLeft to rightBalancedextracellular space, cytosol

Human-GEM MAR09617CC BY 4.0Reference data

L-proline+chloride+2sodium(1+)L-proline+chloride+2sodium(1+)

Transported by SLC6A7 or SLC6A20

Reaction pageDirection not assertedBalanced

Rhea RHEA:71263CC BY 4.0Reference data

L-pipecolate+chloride+2sodium(1+)L-pipecolate+chloride+2sodium(1+)

Transported by SLC6A7 or SLC6A20

Reaction pageDirection not assertedBalanced

Rhea RHEA:71267CC BY 4.0Reference data