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Proteins/UNIPROT:Q8IVL5
Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens. Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4-hydroxyproline in the third position..
Function from UniProtKB (Q8IVL5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
69 statements
69 statements · 5 reference databases · Subject: P3H2 · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways
1 reaction
L-prolyl-[collagen]+2-oxoglutarate(2-)+dioxygentrans-3-hydroxy-L-prolyl-[collagen]+succinate(2-)+carbon dioxide
Catalysed by P3H1 or P3H2 or P3H3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:22872CC BY 4.0Reference data
4 names
Resolves to: P3H2